文献类型：期刊文献

英文题名：New therapeutic insights into radiation-induced myocardial fibrosis

作者：Ma, Cheng-Xu[1];Zhao, Xin-Ke[2];Li, Ying-Dong[1]

第一作者：Ma, Cheng-Xu

通信作者：Li, YD[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Dept Intervent Sect, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2019

卷号：10

起止页码：1

外文期刊名：THERAPEUTIC ADVANCES IN CHRONIC DISEASE

收录：;Scopus(收录号：2-s2.0-85075175697);WOS:【SCI-EXPANDED(收录号:WOS:000480264100001)】；

基金：The author(s) disclosed receipt of the following financial support for the research, authorship, and publication of this article: This work was supported by the National Natural Science Foundation of China (No. 81760798, 81873132).

语种：英文

外文关键词：miRNA; prevention and treatment of RIMF; radiation therapy; radiation-induced myocardial fibrosis (RIMF)

摘要：Radiation therapy (RT) for the treatment of thoracic tumors causes radiation-induced heart disease (RIHD). Radiation-induced myocardial fibrosis (RIMF) is both an acute and chronic stage of RIHD, depending on the specific pathology, and is thought to be a major risk factor for adverse myocardial remodeling and vascular changes. With the use of more three-dimensional conformal radiation regimens and early screenings and diagnoses for RIMF, the incidence of RIHD is declining, but it still must be carefully investigated to minimize the mortality and morbidity of patients with thoracic malignancies after RT treatment. Effective methods for preventing RIMF involve a decrease in the direct radiation dose in the heart, and early screening and diagnosis. Medications remain as a useful adjunct for preventing or treating RIMF. This review mainly discusses the cellular and molecular mechanisms underlying RIMF, and new therapeutic drugs that can potentially be developed from this knowledge.