文献类型：期刊文献

英文题名：A Review of the Pharmacological Action of Astragalus Polysaccharide

作者：Zheng, Yijun[1];Ren, Weiyu[2];Zhang, Lina[3];Zhang, Yuemei[4];Liu, Dongling[1,2];Liu, Yongqi[1]

第一作者：Zheng, Yijun

通信作者：Liu, DL[1];Liu, YQ[1];Liu, DL[2]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Pharm Coll, Lanzhou, Peoples R China;[3]Univ Leeds, Sch Educ, Leeds, W Yorkshire, England;[4]Lanzhou Univ, Hosp 1, Ophthalmol Dept, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Pharm Coll, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2020

卷号：11

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85083094702);WOS:【SCI-EXPANDED(收录号:WOS:000595859600001)】；

基金：This project was supported by the Natural Science Foundation in China (grant numbers 81603407, 81973595).

语种：英文

外文关键词：Astragalus polysaccharide; preparation; chemical composition; pharmacological action; immune regulation; anti-aging; anti-tumor; regulation of blood glucose

摘要：Astragalus membranaceus (A. membranaceus) is a type of traditional Chinese medicine with a long history of clinical application. It is used in the improvement and treatment of various diseases as medicine and food to invigorate the spleen and replenish qi. The main components of A. membranaceus are Astragalus polysaccharide (APS), flavonoids compounds, saponins compounds, alkaloids, etc. APS is the most important natural active component in A. membranaceus, and possesses multiple pharmacological properties. At present, APS possess the huge potential to develop a drug improving or treating different diseases. In this review, we reveal the potential approaches of pre-treating and preparation on APS as much as possible and the study on content of APS and its chemical composition including different monosaccharides. More importantly, this paper summarize pharmacological actions on immune regulation, such as enhancing the immune organ index, promoting the proliferation of immune cells, stimulating the release of cytokines, and affecting the secretion of immunoglobulin and conduction of immune signals; anti-aging; anti-tumor by enhancing immunity, inducing apoptosis of tumor cells and inhibiting the proliferation and transfer of tumor cells; antiviral effects; regulation of blood glucose such as type I diabetes mellitus, type II diabetes mellitus and diabetic complications; lipid-lowering; anti-fibrosis; antimicrobial activities and anti-radiation. It provided theoretical basis for the further research such as its structure and mechanism of action, and clinical application of APS.