文献类型：期刊文献

中文题名：“疏肝调神”配穴针刺对创伤后应激障碍睡眠障碍大鼠睡眠周期的影响

英文题名：Effects of‘soothing the liver and regulating the mind'adjunct points acupuncturing on sleep cycle in rats with post-traumatic stress disorder sleep disorder

作者：赵中亭[1];陈家涟[1];王小花[1];朱田田[1];刘安国[1];严兴科[1]

第一作者：赵中亭

机构：[1]甘肃中医药大学,兰州730101

第一机构：甘肃中医药大学

年份：2024

卷号：39

期号：3

起止页码：1475

中文期刊名：中华中医药杂志

外文期刊名：China Journal of Traditional Chinese Medicine and Pharmacy

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金地区项目(No.81560791);中国博士后科学基金面上项目(No.2017M623269)。

语种：中文

中文关键词：针刺;疏肝调神;创伤后应激障碍;睡眠障碍;动物模型;睡眠周期;脑电波

外文关键词：Acupuncture;Soothing the liver and regulating the mind;Post-traumatic stress disorder;Sleep disorders;Animal model;Sleep cycle;Electroencephalogram

摘要：目的:观察“疏肝调神”配穴针刺对创伤后应激障碍(PTSD)模型大鼠昼间12h异常睡眠周期的影响。方法:60只大鼠随机分为手术组、模型组、抓取组、西药组和针刺组,每组12只。除手术组外均行手术埋置电极与插座并以复合应激法造模,造模后西药组、针刺组及抓取组分别予以盐酸帕罗西汀、“疏肝调神”针法干预和抓取固定。记录昼间12h睡眠脑电,获取睡眠潜伏期、觉醒-睡眠周期和睡眠时相。结果:与手术组比较,模型组大鼠睡眠潜伏期、觉醒期延长(P<0.01),各睡眠期和8:00—9:00、15:00—18:00睡眠缩短(P<0.01,P<0.05);与抓取组比较,西药组、针刺组大鼠睡眠潜伏期、觉醒期均缩短(P<0.01),西药组大鼠各睡眠期和8:00—10:00、14:00—16:00睡眠延长(P<0.01,P<0.05),针刺组大鼠各睡眠期和8:00—9:00、12:00—13:00、15:00—18:00睡眠延长(P<0.01,P<0.05);与西药组比较,针刺组大鼠睡眠在9:00—10:00较短、16:00—17:00较长(P<0.05)。结论:“疏肝调神”配穴针刺和盐酸帕罗西汀均可调节PTSD睡眠障碍模型大鼠异常脑电,改善睡眠,但针刺相对于药物干预针对性强,不会引起嗜睡,效应更稳定。
Objective:To observe the effects of soothing the liver and regulating the mind'adjunct points acupuncturing on 12-hour daytime abnormal sleep cycle in post-traumatic stress disorder(PTSD)model rats.Methods:Sixty rats were randomly divided into operation group,model group,grasping group,medicine group and acupuncture group,12 rats in each group.Except the eperation group,the PTSD sleep disorder rat model was established by compound stress method after the electrode and socket were implanted.After modeling,the medicine group,acupuncture group,and grasping group were respective with paroxetine hydrochloride,'soothing the liver and regulating the mind'acupuncture intervention,and grasping fixation.The daytime 12 h sleep electroencephalogram(EEG)was recorded to obtain sleep latency,wakeing-sleep cycle and sleep phase.Results:Compared with the operation group,the sleep latency and wake period of the model group were prolonged(P<0.01),every sleep period and 8:00-9:00 and 15:00-18:00 sleep were shortened(P<0.01,P<0.05).Compared with grasping group,sleep latency and wake period of rats in medicine group and acupuncture group were shortened(P<0.01),every sleep period and sleep from 8:00 to 10:00 and 14:00 to 16:00 of rats in medicine group were prolonged(P<0.01,P<0.05).In the acupuncture group,every sleep period and the sleep of the rats from 8:00-9:00,12:00-13:00,15:00-18:00 were prolonged(P<0.01,P<0.05).Compared with the medicine group,the sleep of rats in the acupuncture group was shorter from 9:00-10:00 and longer from 16:00-17:00(P<0.05).Conclusion:‘Soothing the liver and regulating the mind'adjunct points acupuncture and Paroxetine Hydrochloride can regulate abnormal EEG and improve sleep in PTSD sleep disorder model rats.However,compared with drug intervention,acupuncture is more targeted,dose not cause drowsiness,and its effect is more stable.