文献类型：期刊文献

中文题名：磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)信号通路参与哮喘气道炎症反应的研究现状

英文题名：Research of phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway involved in airway inflammation of asthma

作者：庞亚蓉[1];席建宏[1];王志旺[1,2];杜玥[1];李济阳[1];丁茂鹏[1];韦凌霞[1];蔺兴遥[1,2]

第一作者：庞亚蓉

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃中医药大学科研实验中心,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2021

卷号：37

期号：14

起止页码：1897

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金资助项目(81460668);甘肃省自然科学基金资助项目(20JR5RA183,1606RJZA011,1310RJZA086);甘肃省中医药研究中心开放基金课题基金资助项目(zyzx-2020-zx4)。

语种：中文

中文关键词：磷脂酰肌醇3激酶/蛋白激酶B信号通路;哮喘;气道炎症;研究进展

外文关键词：phosphatidylinositol 3-kinase/protein kinase B signaling pathway;asthma;airway inflammation;research progress

摘要：哮喘是一种常见且易反复发作的气道免疫炎症疾病,多种细胞及其组分可共同参与并促进其病理过程。气道炎症是哮喘的基本特征,可引起气道高反应,常表现为炎症细胞的增加及炎性细胞的浸润。磷脂酰肌醇3激酶(phosphatidylinositol 3-kinase,PI3K)的活化可导致丝氨酸/苏氨酸蛋白激酶(serine/threonine protein kinase,Akt)的募集、磷酸化,活化的Akt可磷酸化一系列细胞内蛋白从而介导下游反应。近年来,越来越多的研究表明PI3K/Akt信号通路与哮喘气道炎症紧密相关,可通过多机制影响哮喘及其气道炎症的进展。本文就近年来PI3K/Akt信号通路参与哮喘气道炎症反应的发生发展进行综述,为研究哮喘的临床治疗及平喘药物的开发提供理论基础。
Asthma is a common and recurrent airway immune inflammatory disease,a variety of cells and cellular components participate in it and promote its pathological process.As the basic feature of asthma,airway inflammation,can cause airway hyperresponsiveness and often manifested as an increase of inflammatory cells and infiltration of inflammatory cells.The activation of phosphatidylinositol 3-kinase(PI3K)can lead to the recruitment and phosphorylation of serine/threonine protein kinase(Akt),and activated Akt can further phosphorylate a series of intracellular proteins to mediate downstream reactions.In recent years,more and more studies have shown that PI3K/Akt signaling pathway is closely related to asthma airway inflammation,which can affect the progress of asthma and airway inflammation through multiple mechanisms.In this review,PI3K/Akt signaling pathway is involved in the occurrence and development of airway inflammation in asthma in recent years,so as to provide theoretical basis for the clinical treatment of asthma and the development of antiasthmatic drugs.