文献类型：期刊文献

中文题名：间充质干细胞治疗单倍体造血干细胞移植后胃肠道重度GVHD一例并文献复习

英文题名：Mesenchymal stem cells for treatment of severe gastrointestinal graft-versus-host disease after haploid hematopoietic stem cell transplantation: a case report and literature review

作者：张杉杉[1,2];张茜[1,2]

第一作者：张杉杉

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]中国人民解放军联勤保障部队第九四〇医院血液科,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：34

期号：1

起止页码：122

中文期刊名：海南医学

外文期刊名：Hainan Medical Journal

基金：甘肃省自然科学基金(编号:21JRIRA183);联勤保障部队第九四〇医院基础和临床培育项目(编号:2021yxky042)。

语种：中文

中文关键词：间充质干细胞;单倍体;造血干细胞移植;胃肠道;移植物抗宿主病

外文关键词：Mesenchymal stem cells;Haploid;Hematopoietic stem celltransplantation;Thegastrointestinal;Graft-versus-host disease

摘要：异基因造血干细胞移植(allo-HSCT)是目前治疗恶性血液疾病的主要方法,单倍体造血干细胞移植(haplo-HSCT)作为其中一种方法,可使多数患者明显获益,但易并发移植物抗宿主病(GVHD)。目前治疗GVHD的一线方案为糖皮质激素,但仍有部分患者对激素耐药,导致预后不佳。间充质干细胞(MSCs)是一种具有自我更新能力和多向分化能力的非造血干细胞,可调节多种免疫细胞,并在一定条件下发挥免疫抑制作用,对GVHD有良好的治疗作用。本文报道1例haplo-HSCT后并发重度胃肠道GVHD (GI-GVHD)的患者经MCSs治疗后痊愈,并进行文献复习,旨在为临床治疗激素耐药型重度GI-GVHD患者提供思路。
Allogeneic hematopoietic stem cell transplantation(allo-HSCT) is the main method for the treatment of hematological malignancies. Haploid hematopoietic stem cell transplantation(haplo-HSCT), as one of the methods,can bring significant benefits to most patients, but it is prone to be complicated by graft-versus-host disease(GVHD). At present, glucocorticoids are the first-line regimen for the treatment of GVHD, but some patients are still resistant to hormones, resulting in poor prognosis. Mesenchymal stem cells(MSCs) are non-hematopoietic stem cells with self-renewal ability and multidirectional differentiation ability, which can regulate a variety of immune cells and exert immunosuppressive effects under certain conditions, and have a good therapeutic effect on GVHD. In this paper, a case of severe gastrointestinal GVHD(GI-GVHD) after haplo-HSCT was reported and recovered after MCSs treatment, and the literature was reviewed, aiming to provide ideas for clinical treatment of severe GI-GVHD patients with hormone resistance.