文献类型：期刊文献

英文题名：Versatile Surgical Adhesive and Hemostatic Materials: Synthesis, Properties, and Application of Thermoresponsive Polypeptides

作者：Lu, Dedai[1];Wang, Hongsen[1];Li, Ting'e[1];Li, Yunfei[1];Wang, Xiangya[1];Niu, Pengfei[1];Guo, Hongyun[2];Sun, Shaobo[3];Wang, Xiaoqi[2];Guan, Xiaolin[1];Ma, Hengchang[1];Lei, Ziqiang[1]

第一作者：Lu, Dedai

通信作者：Lu, DD[1]

机构：[1]Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China;[2]Gansu Prov Canc Hosp, Inst Gansu Med Sci Res, Lanzhou 730050, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China

通信机构：[1]corresponding author), Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Ecoenvironm Related Polymer Mat, Minist Educ,Key Lab Polymer Mat Gansu Prov, Lanzhou 730070, Gansu, Peoples R China.

年份：2017

卷号：29

期号：13

起止页码：5493

外文期刊名：CHEMISTRY OF MATERIALS

收录：;EI(收录号：20172803941838);Scopus(收录号：2-s2.0-85022322145);WOS:【SCI-EXPANDED(收录号:WOS:000405535700009)】；

基金：National Natural Science Foundation of China (51103118, 21504070).

语种：英文

外文关键词：Adhesion - Bond strength (materials) - Ring opening polymerization - Surgery - Tissue - Tissue engineering

摘要：In this study, thermoresponsive and mussel-inspired polypeptides were synthesized using ring-opening polymerization of a-amino acid derivatives of N-carboxyanhydride (NCA). The tissue adhesive properties of these polypeptides were evaluated using in vitro adhesive strength tests on porcine skin and bone. The results indicated that the species of the functional polypeptide side groups and the adhesive temperature have a significant influence on the adhesion strength. The maximum of the lap-shear adhesion strength on porcine skin was 101.2 kPa, and the maximum of tensile adhesion strength on bone was 603 kPa. The in vivo antibleeding activity and tissue adhesive ability were also evaluated using a rat model. These polypeptides exhibited superior hemostatic properties and healing effects in the skin incision and osteotomy gap, and the skin incision healing and osteotomy gap remodeling were completed in all rats after 2-9 weeks. These polypeptides are expected to be good candidates for surgical tissue adhesives, tissue engineering materials, and antibleeding materials, etc.