文献类型：期刊文献

英文题名：The Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma

作者：Song, Bangguo[1];Chen, Shupeng[4];Zhang, Yang[5,6];Hu, Jihong[2,2,3,3]

第一作者：Song, Bangguo

通信作者：Hu, JH[1]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Clin Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China;[3]Key Lab Tradit Chinese Herbs & Prescript Innovat &, Lanzhou, Peoples R China;[4]Jiangxi Univ Tradit Chinese Med, Sch Clin Med, Nanchang, Jiangxi, Peoples R China;[5]Minist Educ, Key Lab Dunhuang Med & Transformat, Lanzhou, Gansu, Peoples R China;[6]Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：19

起止页码：73

外文期刊名：BIOLOGICS-TARGETS & THERAPY

收录：WOS:【ESCI(收录号:WOS:001443308200001)】；

基金：Acknowledgment We sincerely appreciate Yingjian Zeng for his help and guidance during the revision process. The authors acknowledge the supported by Key Laboratory of Traditional Chinese Herbs and Prescription Innovation and Transformation of Gansu Province (FYWJ-24-01) ;Open Subjects of the Key Laboratory of Dunhuang Medicine, Ministry of Education (DHYX20-17) ; Gansu Provincial Administration of Traditional Chinese Medicine Scientific Research Project (GZKP-2023-42) ;The National Natural Science Foundation of China (82260914) .

语种：英文

外文关键词：asthma; PI3K; inflammation; airway remodeling; inhibitor; immune responses

摘要：Bronchial asthma is a complex and heterogeneous disease with ongoing airway inflammation and increased airway responsiveness. Key characteristics of the disease include persistent airway inflammation, airway hyperresponsiveness, and airway remodeling. Asthma's chronic and recurrent characteristics contribute to airway remodeling and inflammation, which can exacerbate lung damage. Presently, inflammation is predominantly managed with corticosteroids, yet there is a notable absence of treatments specifically addressing airway remodeling. The phosphoinositide 3-kinase (PI3K) signaling pathway is integral to the processes of inflammation, airway remodeling, and immune responses. Pharmacological agents targeting this pathway are currently undergoing clinical evaluation. This review elucidates the role of PI3K in the immune responses, airway inflammation, and remodeling associated with asthma, examining its underlying mechanisms. Furthermore, we synthesize the existing literature on the therapeutic potential of PI3K inhibitors for asthma management, emphasizing immune modulation, airway inflammation, and remodeling, including drug development and ongoing clinical trials. Lastly, we explore how various PI3K-targeted therapies may enhance efficacy and improve tolerance.