文献类型：期刊文献

英文题名：Effect and mechanism of verbascoside on hypoxic memory injury in plateau

作者：Li, Maoxing[1,2,3,4];Zhu, Yuting[1,2,3];Li, Jing[1,2];Chen, Liping[1,2];Tao, Wendi[1,2,3];Li, Xiaoling[1,2,4];Qiu, Yan[5]

第一作者：Li, Maoxing

通信作者：Li, MX[1]

机构：[1]940th Hosp Joint Logist Support Force, Dept Pharm, PLA, 333 South Binghe Rd, Lanzhou 730050, Gansu, Peoples R China;[2]Key Lab Prevent & Treatment Injure Plateau PLA, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Dept Pharm, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Pharm, Lanzhou, Gansu, Peoples R China;[5]Shanghai Univ Med & Hlth Sci, Pudong Hosp, Dept Pharm, Shanghai, Peoples R China

第一机构：940th Hosp Joint Logist Support Force, Dept Pharm, PLA, 333 South Binghe Rd, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force, Dept Pharm, PLA, 333 South Binghe Rd, Lanzhou 730050, Gansu, Peoples R China.

年份：2019

卷号：33

期号：10

起止页码：2692

外文期刊名：PHYTOTHERAPY RESEARCH

收录：;Scopus(收录号：2-s2.0-85073306256);WOS:【SCI-EXPANDED(收录号:WOS:000479473900001)】；

基金：Natural Science Foundation of Gansu Province, Grant/Award Number: 17JR5RA332; Top military medical science and technology youth training project, Grant/Award Number: 16QNP055; Natural Science Foundation of Gansu Province, China, Grant/Award Number: 17JR5RA332; Top Project of Medical Technology for youth, Grant/Award Number: 16QNP055

语种：英文

外文关键词：apoptosis; eight-arm maze; hypoxia memory impairment; mTOR signaling pathway; oxidative stress; verbascoside

摘要：Verbascoside is a water-soluble natural phenylethanoid glycoside and distributes widely in plants. It has been proved with antioxidant, neuroprotective, anti-inflammatory, antibacterial, and immunomodulatory bioactivities. In this experiment, the effect and mechanism of verbascoside on hypoxic memory injury were studied in a low-pressure and low-oxygen chamber. Verbascoside (50, 150, and 300 mg/kg) was intragastrically administered once a day for 7 days. On the fourth day, rats were placed in the chamber to simulate a 7,500 m high-altitude environment The eight-arm maze was used to test the memory ability. The levels of MDA, GSH, and T-SOD in plasma, brain-NH, and hippocampus were detected. The mRNA expression of mTOR, P70S6K, and 4E-BP1 in the hippocampus tissue was determined by PCR. The protein expression of P-mTOR, P-P70S6K, P-4E-BP1, and Cleaved Caspase-3 in the hippocampus tissue was determined by western blot. The results indicated that administration with verbascoside could obviously reduce the working memory error, reference memory error, total errors, and total time; relieve the neuron damage in CA(1) region of the hippocampus; and decrease the oxidative stress correlation enzyme activity in plasma, brain, and hippocampus. The amelioration of verbascoside on high altitude-induced memory impairment may be associated with the adjustment of oxidative stress and mTOR signaling pathway.