文献类型：期刊文献

英文题名：Metal stannum exposure increases the risk of congenital heart defects occurence in offspring: A case-control study in Lanzhou

作者：Zhao, Xiaoli[1,2];Ma, Xuejing[1,2];Song, Lifang[1,2];Sun, Jianhao[2];Jiao, Xinjuan[1];Wang, Jian[2];Mao, Baohong[3,4];Liu, Qing[1,2]

第一作者：Zhao, Xiaoli;赵贤兰;赵雪灵;赵小玲

通信作者：Liu, Q[1];Mao, BH[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Matern & ChildCare Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Prov Matern & ChildCare Hosp, Dept Med Educ, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Matern & ChildCare Hosp, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Matern & ChildCare Hosp, Dept Med Educ, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

卷号：411

外文期刊名：INTERNATIONAL JOURNAL OF CARDIOLOGY

收录：;Scopus(收录号：2-s2.0-85196391673);WOS:【SCI-EXPANDED(收录号:WOS:001316358900001)】；

基金：This work was supported by Youth innovation and entrepreneurship personnel training program of Gansu province (No. 2021LQTD10) and the Science and Technology Department Grant of Lanzhou City (No. 2021-1-85; 2022-5-85) .

语种：英文

外文关键词：Congenital heart defects; Metal exposure; Tin; Pregnancy; Maternal blood; Umbilical cord blood

摘要：Background: The purpose of this study was to analyse the association between stannum exposure during pregnancy and congenital heart diseases in offspring. Methods: Based on a prospective birth cohort study conducted in Gansu Maternal and Child Health Hospital from 2010 to 2012, 14,359 pregnant women were followed up using a nested case-control study method. 97 pregnant women whose offspring were diagnosed with CHDs were used as the case group, and 194 pregnant women whose offspring did not suffer from congenital heart diseases were used as the control group in a ratio of 1:2 according to their age and place of birth. Inductively coupled plasma mass spectrometry was used to determine elemental stannum in blood samples from pregnant women hospitalized for delivery and in fetal cord blood samples. Multifactorial logistic regression analysis was used to assess the association between stannum and offspring CHDs. Results: There was a moderate positive correlation between the concentration of stannum in pregnant women's blood and that in umbilical cord blood. A higher concentrations of maternal blood stannum level was associated with a greater risk of CHDs (aOR 3.409, 95%CI 1.785-6.826), isolated CHDs (aOR 4.044, 95%CI 1.803-9.070), multiple CHDs (aOR 2.625, 95%CI 1.137-6.061), patent ductus arteriosus (aOR 2.882, 95%CI 1.443-5.756), atrial septal defects (aOR 3.067, 95%CI 1.406-6.690), ventricular septal defects (aOR 7.414, 95%CI 1.414-38.874). There was a correlation between the maternal and cord blood sample suggesting stannum crosses the placenta.