文献类型：期刊文献

英文题名：Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis

作者：Miao, Yuxin[1,2];Zheng, Tingwei[1,2];Zhang, Qiuning[3];Li, Meixuan[4];Lei, Qihang[1,2];Liu, Qin[1,2];Luo, Hongtao[5];Bai, Huiling[1,2]

第一作者：Miao, Yuxin

通信作者：Liu, Q[1];Bai, HL[1];Liu, Q[2];Bai, HL[2];Luo, HT[3]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China;[4]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;[5]Gansu Prov Hosp TCM, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Gansu Prov Hosp TCM, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：20

期号：1

外文期刊名：RADIATION ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85217274462);WOS:【SCI-EXPANDED(收录号:WOS:001394545300001)】；

基金：Not applicable.

语种：英文

外文关键词：Proton therapy; Radiotherapy; Choroidal melanoma; Meta-analysis

摘要：BackgroundProton beam therapy (PBT) has been gradually introduced for treating choroidal melanoma. This study systematically reviewed clinical reports to evaluate the efficacy and safety of PBT in choroidal melanoma patients.MethodsThis systematic review included all the primary studies involving PBT for choroidal melanoma patients through April 2024. Four publicly accessible databases were searched, and the statistical data were analyzed using STATA 15.0. The outcomes of interest included overall survival (OS), metastasis-free survival, local control rate, and adverse reactions.ResultsA total of six case series involving 1059 patients with choroidal melanoma were included. The random effect model meta-analysis showed that the 2-, 3-, 5-, and 10-year OS rates of patients with choroidal melanoma treated with PBT were 97%, 92%, 73%, and 39%, respectively. The metastasis-free survival rates at 2, 3, and 5 years were 92%, 89%, and 76%, respectively, and the local control rates at 1, 3, 5, and 10 years were 98%, 92%, 94%, and 88%, respectively. Four studies reported adverse reactions. The most common adverse reactions after PBT were glaucoma, optic neuropathy, and cataracts, with incidence rates ranging from 17.9 to 27%, 12.8-64%, and 29.6-39.8%, respectively.ConclusionsThis meta-analysis identified PBT as a vital local treatment strategy against choroidal melanoma. Both OS and local control rates showed excellent results. However, more prospective trials can help compare the efficacy of PBT with typical therapy.