文献类型：期刊文献

英文题名：Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation

作者：Lu, Weijie[1];Deng, Yaoting[1];Liu, Mengyang[1];Hu, Yujie[2];Yang, Kang[1];Wang, Bowen[1];Li, Yanling[1];Wang, Gang[2];Ma, Li[1];Liu, Jiajia[2];Xie, Yaohui[1];Li, Qianrong[1];Liu, Ai[1];Zhang, Xiubin[3];Xie, Ping[4]

第一作者：Lu, Weijie

通信作者：Xie, P[1]

机构：[1]Gansu Univ Tradit Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Lanzhou Univ, Sch Clin Med, Lanzhou, Gansu, Peoples R China;[3]940th Hosp Peoples Liberat Army Joint Logist Suppo, Dept Crit Care Med, Lanzhou, Gansu, Peoples R China;[4]Gansu Prov Peoples Hosp, Cardiol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学中西医结合学院

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Cardiol, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：12

期号：1

外文期刊名：CELL DEATH DISCOVERY

收录：;Scopus(收录号：2-s2.0-105027000597);WOS:【SCI-EXPANDED(收录号:WOS:001657982300005)】；

基金：All figures in this article were created using BioRender; we gratefully acknowledge the BioRender platform. We also thank the National Natural Science Foundation (8246020036), the Major Collaborative Project of the Gansu Provincial Department of Science and Technology (24JRRA886), the Graduate Student Innovation and Entrepreneurship Program of Gansu University of Chinese Medicine (2025CXZX-917), and the In-Hospital Research Fund of Gansu Provincial People's Hospital (24GSSYE-15) for financial support.

语种：英文

摘要：Acetylation is an important post-translational modification (PTM) of proteins and plays critical roles in multiple biological processes. The modes of cell death represent different pathways leading to the final outcome of "death" for the cell, with apoptosis, ferroptosis, and pyroptosis being the most common forms of cell death. In recent years, research has found that acetylation modifications influence various biological processes, ultimately playing a role in the regulation of apoptosis, ferroptosis, and pyroptosis. This article introduces the molecular effects of acetylation and enzyme/non-enzyme regulation, systematically summarizing the regulatory mechanisms of apoptosis, ferroptosis, and pyroptosis. It ultimately focuses on the genes and proteins associated with the regulation of apoptosis, ferroptosis, and pyroptosis, providing a comprehensive explanation of how acetylation regulates these processes. Given that the mode of cell death may be singular or coexist with two or more types in certain diseases, this article aims to conduct an in-depth analysis of the regulatory role of a specific PTM of proteins (acetylation) on different cell death pathways. Furthermore, it seeks to summarize potential key pathways or targets through which acetylation influences the interplay of various cell death mechanisms. By intervening in multiple cell death pathways, this study aims to provide insights for the prevention and treatment of tumors and cardiovascular diseases, both of which are closely related to outcomes associated with cell death.