详细信息

Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19  ( SCI-EXPANDED收录)   被引量:5

文献类型:期刊文献

英文题名:Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19

作者:Lu, Zhen-Hua[1];Zhou, Hao-Wei[1,2];Wu, Wei-Kang[1,3];Fu, Ting[1];Yan, Min[1];He, Zhen[1];Sun, Shi-Wei[1,2];Ji, Zhao-Hua[1];Shao, Zhong-jun[1]

第一作者:Lu, Zhen-Hua

通信作者:Ji, ZH[1];Shao, ZJ[1]

机构:[1]Air Force Med Univ, Sch Publ Hlth, Minist Educ, Dept Epidemiol,Key Lab Hazard Assessment & Contro, Xian, Peoples R China;[2]Baotou Med Coll, Sch Publ Hlth, Baotou, Peoples R China;[3]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China

第一机构:Air Force Med Univ, Sch Publ Hlth, Minist Educ, Dept Epidemiol,Key Lab Hazard Assessment & Contro, Xian, Peoples R China

通信机构:[1]corresponding author), Air Force Med Univ, Sch Publ Hlth, Minist Educ, Dept Epidemiol,Key Lab Hazard Assessment & Contro, Xian, Peoples R China.

年份:2021

卷号:11

外文期刊名:FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

收录:;Scopus(收录号:2-s2.0-85120907772);WOS:【SCI-EXPANDED(收录号:WOS:000729164100001)】;

基金:This work was supported by the National Natural Science Foundation of China (81803289, 81773488), the Natural Science Foundation of Shaanxi Province (2020JM-329), the Military Medicine Innovation Fund (18CXZ011), and China Special Grant for the Prevention and Control of Infection Diseases (2017ZX10105011). The funding agencies had no role in the study design, data collection and analysis, or preparation of the manuscript.

语种:英文

外文关键词:COVID-19; gut virome; bacteriome; bacteriophage; virus-bacteria linkages

摘要:Patients with Coronavirus Disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with respiratory issues and related symptoms, in addition to significantly affected digestive system, especially the intestinal tract. While several studies have shown changes in the intestinal flora of patients with COVID-19, not much information is available on the gut virome of such patients. In this study, we used the viromescan software on the latest gut virome database to analyze the intestinal DNA virome composition of 15 patients with COVID-19 and investigated the characteristic alternations, particularly of the intestinal DNA virome to further explore the influence of COVID-19 on the human gut. The DNA viruses in the gut of patients with COVID-19 were mainly crAss-like phages (35.48%), Myoviridae (20.91%), and Siphoviridae (20.43%) family of viruses. Compared with healthy controls, the gut virome composition of patients with COVID-19 changed significantly, especially the crAss-like phages family, from the first time of hospital admission. A potential correlation is also indicated between the change in virome and bacteriome (like Tectiviridae and Bacteroidaceae). The abundance of the viral and bacterial population was also analyzed through continuous sample collection from the gut of patients hospitalized due to COVID-19. The gut virome is indeed affected by the SARS-CoV-2 infection, and along with gut bacteriome, it may play an important role in the disease progression of COVID-19. These conclusions would be helpful in understanding the gut-related response and contribute to the treatment and prevention strategies of COVID-19.

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