文献类型：期刊文献

英文题名：Advances in molecular mechanisms of acupuncture in chronic pain with depression

作者：Ma, Cui[1];Wei, Yu-ting[1];Liu, An-guo[1];Ye, Yu-juan[1];Lu, Hong-yu[1];Yan, Xing-ke[1]

第一作者：马春;马程

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学针灸推拿学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Peoples R China.|[10735db5df93766a96e5b]甘肃中医药大学针灸推拿学院;[10735]甘肃中医药大学;

年份：2026

卷号：36

期号：1

起止页码：67

外文期刊名：WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION

收录：Scopus(收录号：2-s2.0-105027263597);WOS:【ESCI(收录号:WOS:001721471700001)】；

基金：Supported by General Project of Gansu Provincial Joint Research Fund: 25JRRA1173; 2023 Gansu Provincial Key Talent Program: No. 2023 [20] ; Key Project of Scientific Research and Innovation Fund of Gansu University of Chinese Medicine: 2023KCZD-6; 2025 Gansu Provincial Higher Education Innovation Fund Project: 2025A-104; 2025 Gansu Provincial Graduate "Innovation Star" Project: 2025CXZX-936; 2025 Gansu University of Chinese Medicine Graduate "Innovation and Entrepreneurship Fund" Project: 2025CXCY-001.

语种：英文

外文关键词：Acupuncture; Chronic pain; Depression; Molecular biology; Multidimensional regulation

摘要：Chronic pain is often accompanied by depressive emotions, and they are interacted with each other, which is one of the crucial factors to affect the clinical efficacy on pain. Acupuncture therapy has the advantages of multi-dimensional and multi-target regulation, and it is remarkably effective on chronic pain and pain-related depressive emotions. This paper reviews the mechanism researches of acupuncture in treatment of chronic pain with depression. Research indicates that the primary molecular mechanism by which acupuncture exerts analgesic and anti-depressive effects involves the regulation of central nervous system neurotransmitters, including 5-hydroxytryptamine, glutamic acid, gamma-aminobutyric acid, and dopamine. Additionally, acupuncture inhibits inflammatory responses within the central nervous system, modulates the expression of neurotrophic factors, enhances neuronal synaptic plasticity, and regulates the BDNF/TrkB/CREB and ERK signaling pathways. These findings underscore the multifaceted and multi-targeted regulatory advantages of acupuncture. Copyright (c) 2026 World Journal of Acupuncture-Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/)