文献类型：期刊文献

英文题名：Improving the transparency of animal experiments: valuable lessons learned from a systematic analysis of registration protocols

作者：Yi, Shaowei[1,4,5];Ruan, Jianhua[1,4,5];Wang, Zhe[1,4,5];Ding, Fengxing[1,4,5];Liu, Yanli[1,4,5];Ao, Qi[2];Ren, Ziyu[2];Wu, Caizhi[1,4,5];Luo, Yating[1,4,5];Niu, Muting[2];Zhao, Yue[2];Wang, Youhu[3];Ma, Bin[1,2,4,5,6]

第一作者：Yi, Shaowei

通信作者：Ma, B[1];Ma, B[2];Wang, YH[3];Ma, B[4];Ma, B[5];Ma, B[6]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[3]Lanzhou Univ, Hosp 1, Dept Otorhinolaryngol Head & Neck Surg, Lanzhou 730000, Peoples R China;[4]Lanzhou Univ, Res Ctr Med Device Regulatory Sci, Lanzhou 730000, Peoples R China;[5]Ind Ctr Evidence Based Res & Evaluat Stand Med Dev, Lanzhou 730000, Peoples R China;[6]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Key Lab Evidence Based Med & Knowledge Translat Ga, 199 Donggang West Rd, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[3]corresponding author), Lanzhou Univ, Hosp 1, Dept Otorhinolaryngol Head & Neck Surg, Lanzhou 730000, Peoples R China;[4]corresponding author), Lanzhou Univ, Res Ctr Med Device Regulatory Sci, Lanzhou 730000, Peoples R China;[5]corresponding author), Ind Ctr Evidence Based Res & Evaluat Stand Med Dev, Lanzhou 730000, Peoples R China;[6]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Key Lab Evidence Based Med & Knowledge Translat Ga, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2026

卷号：22

期号：1

外文期刊名：BMC VETERINARY RESEARCH

收录：;Scopus(收录号：2-s2.0-105040380553);WOS:【SCI-EXPANDED(收录号:WOS:001775845400001)】；

语种：英文

外文关键词：Animal experimentation; Animal experimentation registration; Translation of animal research; Registration platform; Registration protocol

摘要：Purpose To comprehensively analyze the epidemiological characteristics of research protocols on international animal experiment registration platforms, explore potential factors influencing protocol publication, and offer recommendations to improve animal experiment registration systems. Methods Research protocols registered on the Netherlands' PCT(Preclinical Trials) and Germany's ASR(Animal Study Registry) animal experiment registration platforms up to December 30, 2024, were included. Relevant data were extracted, and frequency distributions and percentages were calculated to statistically describe the findings. Factors influencing publication rates were identified using chi-square tests and multivariate binary logistic regression analysis. Results A total of 272 registered protocols were analyzed, including 124 from the PCT platform and 148 from the ASR platform, originating from 31 countries, spanning 47 research areas, and involving 11 different animal species. Among the studies, 10.0% (27/272) did not report randomization, and none of the randomized studies (132/272) addressed allocation concealment. Additionally, 24.6% (67/272) and 35.3% (96/272) failed to report blinding during intervention implementation and outcome measurement, respectively. Only 43.3% (97/224) of the experiments were completed within the specified timeframe, and among these, merely 23.7% (23/97) achieved full publication. Animal species were identified as potential influencing factors. Studies using pigs as animal models were more frequently published. Conclusion As a vital measure to enhance the quality of animal experiments, the registration of animal protocols requires joint emphasis and coordinated promotion by multiple stakeholders, including researchers, research institutions, ethics committees, journal editors, funding agencies, and regulatory authorities. Strengthening protocol registration will not only improve transparency, reproducibility, and ethical oversight, but also build a more trustworthy foundation for high-quality evidence and accelerate the clinical translation of animal research.