文献类型：期刊文献

英文题名：Effect of esketamine-based patient-controlled intravenous analgesia on postoperative pain and quality of recovery after video-assisted thoracoscopic lobectomy: A prospective, double-blind, randomized controlled trial

作者：Bi, Ruirui[1];Zhang, Jiqiang[2];Liu, Ruijuan[3];Li, Lijuan[2];Su, Yuxi[2];Xu, Mengjun[3];Yan, Wenjun[3]

第一作者：Bi, Ruirui

通信作者：Yan, WJ[1]

机构：[1]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Anesthesiol,Med Sch, Nanjing, Jiangsu, Peoples R China;[2]Gansu Univ Chinese Med, First Clin Med Coll, Gansu Prov Hosp, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Hosp, Dept Anesthesiol, Lanzhou, Gansu, Peoples R China

第一机构：Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Anesthesiol,Med Sch, Nanjing, Jiangsu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Anesthesiol, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：21

期号：1

外文期刊名：PLOS ONE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001681221800006)】；

基金：This study was supported by National Natural Science Foundation of China [No. 81860233], Lanzhou Science and Technology Bureau's special medical and health project [No. 2023-1-47], Gansu Provincial Natural Science Foundation [No. 21JR7RA621], Gansu Province Anesthesia and Brain Function Clinical Medical Research Center [No. 21JR7RA675], Key Research and Development Plan of Gansu Province - Social Development Category [No. 23YFFA0046] and Gansu Province Key Talent Project [No. 2023RCXM13]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种：英文

摘要：Objective This double-blinded randomized study aimed to investigate the effects of esketamine-based patient-controlled intravenous analgesia (PCIA) on postoperative analgesia and quality of recovery in patients undergoing video-assisted thoracoscopic (VATS) lobectomy. Methods Patients undergoing selective VATS lobectomy were enrolled and randomly assigned (1:1) to receive PICA with 1.5 mg/kg esketamine (group K) or 1.5 mg/kg sufentanil (group S). Pain intensity was evaluated using the short-form of the McGill Pain Questionnaire (SF-MPQ) and the visual analog scale (VAS). The primary endpoint was the SF-MPQ score of patients on postoperative day 1. Results Between December 2021 and May 2022, 84 eligible patients received the allocated treatment, with 80 patients (40 per group) ultimately included in the analysis. The total SF-MPQ score in group K was lower than that in group S on postoperative day 1 (P < 0.001) and day 2 (P < 0.001). Additionally, the VAS-rest, VAS-movement and patients' depression-related scores in group K were all significantly lower than those in group S on postoperative day 1 (P = 0.012, P = 0.008 and P = 0.009, respectively) and day 2 (all P < 0.001), whereas the postoperative recovery quality was significantly higher in group K than that in group S on postoperative days 1 and 2 (both P < 0.001). A lower incidence of total adverse events (AEs) was observed in group K than in group S (15% vs. 35%, P = 0.039). Conclusion The use of 1.5 mg/kg esketamine in PCIA for postoperative analgesia in patients undergoing VATS lobectomy showed a promising analgesic effect and improved perioperative depression and postoperative recovery quality, with no severe AEs observed.