文献类型：期刊文献

中文题名：肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响

英文题名：Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease

作者：孙杰[1];王俊霞[1];赵鸿亮[1];吴立文[1]

第一作者：孙杰

机构：[1]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2007

卷号：13

期号：8

起止页码：36

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD

基金：甘肃省中医管理局资助课题(2004-GZK-07)

语种：中文

中文关键词：肺心通;慢性肺源性心脏病;一氧化氮;内皮素-1;血管内皮细胞生长因子

外文关键词：Feixintong; chronic pulmonary heart disease ; NO ; ET-1 ; VEGF

摘要：目的:探讨肺心通对慢性肺源性心脏病(CPHD)大鼠的治疗效果及其作用机理。方法:50只Wistar大鼠,雌雄各半,随机分为空白组、模型组、肺心通高、中、低剂量组,以2%野百合碱(MCT)按60 mg/kg 1次腹腔注射复制CPHD大鼠模型。同时给模型组、肺心通高、中、低剂量组灌胃相应药物,连续用药21 d。测定大鼠血清和肺组织匀浆中一氧化氮(NO)、内皮素-1(ET-1)的含量;测定肺小动脉及支气管平滑肌血管内皮细胞生长因子(VEGF)的表达;观察肺组织病理形态学改变。结果:肺心通可显著提高CPHD模型大鼠的NO含量;降低ET-1的含量;降低大鼠肺小动脉及支气管平滑肌中VEGF的表达;改善肺组织的病理改变。结论:肺心通对CPHD大鼠有较好的治疗作用。
Objective：To research the functionary mechanism and treating effect of Feixintong（FXT） on chronic pulmonary heart disease（ CPHD）. Methods：50 Wister rats were randomly separated into five groups：blank control group, model group, FXT groups of high, middle and low dosage, The rat model of corpulmonale was established by injecting 2 % monocrotaline（60 mg/kg）i, p. At the same time, model group, FXT groups of high, middle and low dosage were separately administrated with physical saline or FXT for 21 days. NO, ET-1 and expression of VEGF in bronchi arterioles was measured. Lung tissue sections were examined to study the morphological alternations. Results： FXT could evidently improve the NO content of rat model of CPHD; reduce the ET-1 content： reduce the expression of VEGF in bronchi arterioles. Conclusions：FXT treatment is effective on rat model of CPHD.