文献类型：期刊文献

中文题名：基于中医瘀血理论探讨干燥综合征的发病机制及治疗

英文题名：Discussion on Pathogenesis and Treatment Progress of Sjogren’s Syndrome Based on Blood Stasis Theory of Traditional Chinese Medicine

作者：漆文霞[1];王钢[2];闫彦峰[3];王佳[2];田杰祥[2];王丽琴[2];姜刚刚[1]

第一作者：漆文霞

机构：[1]甘肃中医药大学中西医结合学院,兰州730000;[2]甘肃中医药大学附属医院,兰州730020;[3]甘肃中医药大学第四附属医院,兰州730060

第一机构：甘肃中医药大学中西医结合学院

年份：2022

卷号：24

期号：11

起止页码：4279

中文期刊名：世界科学技术-中医药现代化

外文期刊名：Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD_E2021_2022】；

基金：国家自然科学基金委员会地区科学基金项目(81860858);基于骨免疫探讨补肾通络法对类风湿关节炎骨破坏及Treg/Th17的影响及机制研究,负责人:王钢;甘肃省中医药管理局科技计划项目(GZK-2019-34):补肾通络方对类风湿关节炎骨破坏疗效及骨代谢的影响研究,负责人:王钢。

语种：中文

中文关键词：干燥综合征;瘀血理论;活血化瘀;发病机制;治疗进展

外文关键词：Sjogren’s syndrome;Blood stasis theory;Promoting blood circulation and removing blood stasis;Pathogenesis;Treatment progress

摘要：干燥综合征(Sjogren’s syndrome,SS)是一种慢性自身免疫性疾病,以免疫细胞浸润、唾液腺和泪腺进行性损伤为主要特征,除了影响泪腺和唾液腺,导致眼睛干涩和口干症状外,还会累及人体皮肤关节、肺、肾和消化、神经及血液等多个系统,严重影响人体身心健康。近年来西医在该病的诊断和治疗方面有了广泛和深入的研究,但目前还没有针对潜在病因的治疗方法。古往今来,众多医家从滋阴润燥、养阴生津方面论治本病取得了一定的疗效。近年来随着研究的进一步深入,很多学者发现本病与瘀血密切相关,活血化瘀法也被证实在治疗本病方面疗效确切。瘀血既是病理产物,同时也是致病因素,本病很多的病理变化都与此相关。本文拟从炎症-细胞因子-凝血系统、血管生成及冷球蛋白血症等方面论述瘀血与本病的相关性,并进一步论证活血化瘀法的临床疗效,以期为后期的研究提供理论依据。
Sjogren’s Syndrome is a chronic autoimmune disease. It is mainly characterized by immune cell infiltration and progressive damage to salivary and lacrimal glands. In addition to affecting lacrimal and salivary glands, resulting in dry eyes and dry mouth, SJ?gren’s syndrome(SS) also involves many systems of human skin, joints, lungs, kidneys,digestion, nerves and blood, seriously affecting human physical and mental health. In recent years, western medicine has made extensive and in depth research in the diagnosis and treatment of this disease, but there is no treatment for the underlying cause. Since ancient times, many doctors have achieved certain curative effects in the treatment of t-his disease from the aspects of Nourishing Yin, moistening dryness, nourishingy in and generating fluid. In recent years, with the further research, many scholars have found that the disease is closely related to blood stasis, and the met-hod of promoting blood circulation and removing blood stasis has also been proven to be effective in treating the disease. Blood stasis is both a pathological product and a pathogenic factor. Many pathological changes of this disease are related to this. This paper intends to discuss the correlation between blood stasis and this disease from the aspects of inflammation cytokine coagulation system, angiogenesis and cryoglobulinemia, and further demonstrate the clinical efficacy of the method of activating blood circulation and removing blood stasis, so as to provide theoretical basis for the later experimental and clinical research of this disease.