文献类型：期刊文献

英文题名：Loperamide poisoning resulting in death: a case report and literature review

作者：Wang, Bowen[1];Zhang, Zhan[1];Chen, Ke[2];Du, Zhongyang[3];Zhang, Tianchen[1];Xie, Ping[1]

第一作者：Wang, Bowen

通信作者：Xie, P[1]

机构：[1]Gansu Prov Hosp, Dept Cardiovasc Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[3]Wushan Cty Hosp Tradit Chinese Med, Dept Cardiovasc Med, Tianshui, Peoples R China

第一机构：Gansu Prov Hosp, Dept Cardiovasc Med, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Cardiovasc Med, Lanzhou, Peoples R China.

年份：2025

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105015074496);WOS:【SCI-EXPANDED(收录号:WOS:001564301500001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This research was supported by the National Natural Science Foundation of China (82460051), the Natural Science Foundation of Gansu Province (23JRRA1287), the Traditional Chinese Medicine Research Project of Gansu Province (GZKZ-2021-7), and the Excellent Doctor Training Program of Gansu Provincial People's Hospital (22GSSYD-14).

语种：英文

外文关键词：loperamide toxicity; cardiotoxicity; QTc interval prolongation; adolescent poisoning; case report

摘要：Loperamide is a medication commonly used to treat acute and chronic diarrhea and is generally considered safe because it poorly crosses the blood-brain barrier at therapeutic doses. However, in recent years, with the abuse and overdose of loperamide, its potential cardiotoxicity and central nervous system depression have increasingly raised concerns. This article reports a case of a 15-year-old male patient who died from poisoning after a single ingestion of 60 mg of loperamide. The patient took a large dose of loperamide 6 h before admission and was found to have respiratory and cardiac arrest 1 h before admission. Despite cardiopulmonary resuscitation and advanced life support treatment, the patient ultimately died from irreversible brain damage. Electrocardiography showed significant QTc interval prolongation, and the plasma loperamide concentration was 50 ng/mL, indicating loperamide's cardiotoxicity. This article, through this case and a review of the literature, discusses the mechanisms of loperamide's cardiotoxicity, clinical manifestations, and treatment strategies, aiming to enhance clinicians' awareness of loperamide poisoning.