文献类型：期刊文献

英文题名：New Insights into the Pathogenesis of Alcoholic Liver Disease Based on Global Research

作者：Zhang, Jinbao[1,2,3,4,5];Yang, Zonghui[1];Liu, Xiaona[1];Yang, Xiujuan[1,2,3,4];Li, Yaling[7];Jin, Xiaojie[1,2,3,7];Duan, Haijing[1,2,3,4];Chen, Honggang[1,2,3,5];Zhao, Wenlong[1,2,3,5];Wang, Qian[6];Liu, Yongqi[7]

第一作者：Zhang, Jinbao;张金保

通信作者：Zhang, JB[1];Zhang, JB[2];Zhang, JB[3];Zhang, JB[4];Zhang, JB[5]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, 35 Dingxi East Rd, Lanzhou, Peoples R China;[2]Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou, Peoples R China;[3]MOE PRC, Lanzhou, Peoples R China;[4]Key Lab Pharmacol & Toxicol TCM Gansu Prov, Lanzhou, Peoples R China;[5]Engn Res Ctr Evaluat Protect & Utilizat Rare Tradi, Lanzhou, Gansu, Peoples R China;[6]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou, Peoples R China;[7]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, 35 Dingxi East Rd, Lanzhou, Peoples R China;[2]corresponding author), Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou, Peoples R China;[3]corresponding author), MOE PRC, Lanzhou, Peoples R China;[4]corresponding author), Key Lab Pharmacol & Toxicol TCM Gansu Prov, Lanzhou, Peoples R China;[5]corresponding author), Engn Res Ctr Evaluat Protect & Utilizat Rare Tradi, Lanzhou, Gansu, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2025

外文期刊名：DIGESTIVE DISEASES AND SCIENCES

收录：;Scopus(收录号：2-s2.0-85217416796);WOS:【SCI-EXPANDED(收录号:WOS:001395432600001)】；

基金：This work was supported by the Natural Science Foundation of Gansu Province (No. 20JR10RA330), Young Doctoral Fund Project of Gansu Province Colleges and Universities (No. 2021QB-076) and Gansu Provincial University Teachers ' Innovation Fund (No. 2025A-107).

语种：英文

外文关键词：Alcoholic liver disease (ALD); Pathogenesis; Intestinal flora; Acetaldehyde dehydrogenase (ALDH); Alcohol dehydrogenase (ADH)

摘要：Background and AimsAlcoholic liver disease (ALD) is the leading cause of death among alcohol-related diseases, yet its pathogenesis remains incompletely understood. This article employs data mining methods to conduct an indepth study of articles on ALD published in the past three decades, aiming to elucidate the pathogenesis of ALD.MethodsFirstly, articles related to the pathogenesis of ALD were retrieved from the Web of Science (WOS) database. CiteSpace 6.1.R2 and VOSviewer 1.6.18 were used to visually analyze the authors, institutions, journals, and keywords of the published articles. Secondly, by thoroughly reading the top 100 most cited articles and focusing on research hotspots such as cytochrome P450 2E1 (CYP2E1), gut microbiota, acetaldehyde dehydrogenase (ALDH), and alcohol dehydrogenase (ADH), the pathogenesis of ALD was preliminarily explored. Finally, the pathogenesis of ALD was further analyzed based on disease databases.ResultsA total of 1521 articles were retrieved from the WOS database, and 384 of these were selected for in-depth reading. From GeneCards, 9084 genes related to ALD were identified. KEGG enrichment analysis was performed using DAVID, and the hsa04936: Alcoholic liver disease pathway was selected for visualization.ConclusionsThis study preliminarily elucidates the pathogenesis of ALD, which may be associated with the release of acetaldehyde, reactive oxygen species (ROS), and various pro-inflammatory factors during alcohol metabolism. It is also closely related to gut microbiota dysbiosis and increased intestinal permeability induced by multiple factors.