文献类型：期刊文献

中文题名：黑逍遥散干预阿尔茨海默病的述评与展望

英文题名：Hei Xiaoyaosan in Treating Alzheimer's Disease:A Review

作者：吕育洁[1];胡韵韵[1];孟志鹏[1];陈怡琴[1];杨娇[1];王虎平[1,2,3]

第一作者：吕育洁

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省中医方药挖掘与创新转化重点实验室,兰州730000;[3]甘肃省中药新产品创制工程实验室,兰州730000

第一机构：甘肃中医药大学

年份：2024

卷号：30

期号：17

起止页码：43

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(81960828;82160862);甘肃省自然科学基金项目(22JR11RA113);甘肃中医药大学科学研究与创新基金项目(2022KCZD-3);甘肃中医药大学中医学学科导师基金项目(甘中医大科发〔2022〕13号);第五批全国中医临床优秀人才研修项目(国中医药人教函〔2022〕39号);首批陇原青年英才项目(中共甘肃省委人才工作领导小组〔2022〕5号)。

语种：中文

中文关键词：阿尔茨海默病;黑逍遥散;方药;机制;三阴并调

外文关键词：Alzheimer's disease;Hei Xiaoyaosan;prescription;mechanism;regulating three Yin

摘要：阿尔茨海默病(AD)是一种多发于老年人群体的神经退行性疾病,中医将其归为“痴呆”“呆病”的范畴,其发生发展与肾、肝、脾三脏的功能密切相关。肝脾肾“三阴并调”经典名方——黑逍遥散,在治疗神经退行性疾病方面具有广阔前景。该文将综合近10年文献资料,从实验研究出发,归纳总结黑逍遥散方药及其有效成分干预AD的作用机制,发现黑逍遥散具有多靶点、多层次、多环节综合调控AD的协同干预优势。结合临床研究,发现黑逍遥散(或联合其他疗法)治疗AD疗效确切,可有效改善AD患者的认知障碍,降低氧化应激水平和抑制可溶性凋亡因子过度表达。该文基于现代医学背景和常用实验方法,旨在为黑逍遥散治疗AD提供理论依据并探索新的研究方向。甚至为其临床应用和药食同源产品的研发提供新思路。
Alzheimer's disease(AD)is a neurodegenerative disease that predominantly affects the elderly.It belongs to the category of dementia in traditional Chinese medicine(TCM),with the onset and progression closely associated with the functions of the kidney,liver,and spleen.The classic TCM formula Hei Xiaoyaosan,which regulates the three Yin of liver,spleen,and kidney,shows broad prospects in treating neurodegenerative diseases.This article reviews the experimental studies reported in the past decade to summarize the mechanisms of Hei Xiaoyaosan and its active components in intervening in AD.Hei Xiaoyaosan can treat AD via multiple targets,levels,and aspects comprehensively.The clinical studies have demonstrated that Hei Xiaoyaosan alone or in combination with other therapies has a definite therapeutic effect on AD.Specifically,it can ameliorate the cognitive impairment,mitigate oxidative stress,and inhibit the overexpression of soluble apoptotic factors in AD patients.This review aims to provide a theoretical basis for the treatment of AD with Hei Xiaoyaosan and explore new research directions.Moreover,it gives new insights into the clinical application of Hei Xiaoyaosan and the development of products with both medicinal and edible values.