文献类型：期刊文献

中文题名：基于“异病同治”探讨玉屏风散对重症急性呼吸综合征、中东呼吸综合征和新型冠状病毒肺炎的共性作用

英文题名：Co-action effect of Yupingfeng San(玉屏风散)on SARS,MERS and COVID-19 based on“treating different diseases with the same therapy”

作者：徐倩娟[1];曹如冰[1];马清林[1];段海婧[1,2];杜丽东[1,2];宁艳梅[1,2];任远[1,2]

第一作者：徐倩娟

机构：[1]甘肃中医药大学药学院,甘肃兰州730101;[2]甘肃省中药药理与毒理学重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2022

卷号：39

期号：2

起止页码：38

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：甘肃省中药药理与毒理学重点实验室抗新型冠状病毒肺炎专项基金项目(2020-KXG-001)。

语种：中文

中文关键词：玉屏风散;重症急性呼吸综合征;中东呼吸综合征;新型冠状病毒肺炎;异病同治;网络药理学;共性机制;

外文关键词：Yupingfeng San(玉屏风散);severe acute respiratory syndrome(SARS);middle east respiratory syndrome(MERS);corona virus disease 2019(COVID-19);treating different diseases with the same therapy;network pharmacology;co-action mechanism;

摘要：目的采用系统药理学方法分析玉屏风散防治重症急性呼吸综合征(SARS)、中东呼吸综合征(MERS)和新型冠状病毒肺炎(COVID-19)的潜在共性作用及作用机制。方法通过中药系统药理学数据库与分析平台(TCMSP)、pharmGKB、GeneCards、DrugBank、Uni Prot数据库筛选玉屏风散中组方药物化学成分作用靶点及SARS、MERS和COVID-19相关靶点,采用omicshare平台对药物靶点和疾病靶点进行匹配映射,通过STRING数据库构建蛋白质-蛋白质相互作用(PPI)网络,应用Cytoscape软件构建玉屏风散防治SARS、MERS和COVID-19的“成分-靶点-疾病”交互网络图,利用DAVID、KOBAS数据库进行生物过程和通路分析。结果获得玉屏风散防治SARS、MERS和COVID-19的共有靶点21个,相关生物过程42个、信号通路153条。白细胞介素-6、肿瘤坏死因子、血管内皮生长因子A、白细胞介素-10、过氧化物酶体增生激活受体γ等靶点可能是玉屏风散防治SARS、MERS和COVID-19的重要共性靶点,这些靶点与缺氧诱导因子-1、C型凝集素受体、Janus激酶/信号转导子和转录激活子、白细胞介素-17等信号通路以及对非生物刺激的反应、毒物质的反应、氧气水平的反应等生物学过程有关;槲皮素、山奈酚、汉黄芩素、5-O-甲基维阿斯米醇苷、芒柄花黄素、7-O-甲基异丙醇胺等可能是玉屏风散发挥防治作用的重要共性成分。结论玉屏风散对SARS、MERS和COVID-193种冠状病毒感染具有潜在的共性作用,黄酮类化合物可能是玉屏风散防治冠状病毒感染的物质基础,玉屏风散在防治冠状病毒感染方面具有重要的潜在价值。
Objective To analyze the potential co-action effect and mechanism of Yupingfeng San(玉屏风散)on prevention and treatment of severe acute respiratory syndrome(SARS),middle east respiratory syndrome(MERS)and corona virus disease 2019(COVID-19)based on systematic pharmacology approach.Methods The action targets of chemical components of composing prescription of Yupingfeng San and related targets of SARS,MERS and COVID-19 were screened out via traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),pharmGKB,GeneCards,DrugBank and UniProt databases,and omicshare platform was used to match and map drug targets and disease targets,a protein-protein interaction PPI network was constructed via STRING database,and Cytoscape software was used to construct an interactive network diagram of components,targets and diseases for prevention and treatment of SARS,MERS and COVID-19 with Yupingfeng San.The biological processes and pathways were analyzed via DAVID and KOBAS databases.Results Twenty-one common targets for prevention and treatment of SARS,MERS and COVID-19,42 related biological processes and 153 signaling pathways in Yupingfeng San were obtained.The targets of interleukin-6,tumor necrosis factor,vascular endothelial growth factor A,interleukin-10,peroxisome proliferation activated receptorγetc.may be an important common targets for Yupingfeng San to prevent and treat SARS,MERS and COVID-19,which are related to signaling regulatory pathways such as hypoxia inducible factor-1,C-type lectins receptors,Janus kinase/signal transducer and activator of transcription pathway,interleukin-17 as well as multiple biological processes,namely response to abiotic stimulus,response to toxic substance,response to oxygen levels.Quercetin,kaempferol,wogonin,5-O-methylvisamminol,formononetin and 7-O-methylisopropanolamine may be important common components of Yupingfeng San to play the role of prevention and treatment.Conclusion Yupingfeng San has potential common effects on the infection of 3 coronaviruses of SARS,MERS and COVID-19.Flavonoids may be the material basis for the prevention and treatment of coronavirus infection by Yupingfeng San,which has important potential value in the prevention and treatment of coronavirus infection.