文献类型：期刊文献

英文题名：Phosphorylation of polysaccharides: A review on the synthesis and bioactivities

作者：Xia, Shunli[1];Zhai, Yongcong[1];Wang, Xue[1];Fan, Qirui[1];Dong, Xiaoyi[1];Chen, Mei[1];Han, Tao[1,2]

第一作者：Xia, Shunli

通信作者：Han, T[1]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]Key Lab Pharmacol & Toxicol Tradit Chinese Med Ga, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2021

卷号：184

起止页码：946

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20240815604573);Scopus(收录号：2-s2.0-85109198343);WOS:【SCI-EXPANDED(收录号:WOS:000682782900010)】；

语种：英文

外文关键词：Polysaccharide; Phosphorylated modification; Synthesis; Characterization; Biological activity; Structure-activity relationship

摘要：Polysaccharides are macromolecules obtained from a wide range of sources and are known to have diverse biological activities. The biological activities of polysaccharides depend on their structure and physicochemical properties, including water solubility, monosaccharide composition, degree of branching, molecular structure, and molecular weight. Phosphorylation is a commonly used chemical modification method that improves the physicochemical properties of native polysaccharides, thus enhancing their biological activity, or even imparting novel biological activity. Therefore, phosphorylated polysaccharides have attracted increasing attention owing to their antioxidant, antitumor, antiviral, immunomodulatory, and hepatoprotective effects. In this review, we have discussed recent advances in the phosphorylation of polysaccharides, and the methods used for phosphorylation, structural characterization, and determination of biological activities, to provide a theoretical basis for the use of polysaccharides. The structure-activity relationship of phosphorylated polysaccharides and their use in the food and pharmaceutical industries needs to be further studied.