文献类型：期刊文献

英文题名：Research progress on animal models of peritoneal adhesion

作者：Pu, Zhenjun[1];Nian, Hongyu[1];Li, Zhiyuan[1];Zhong, Pengfei[1];Ma, Shengxu[1];Li, Junliang[1,2,3,4,5]

第一作者：Pu, Zhenjun

通信作者：Li, JL[1]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, 204 Donggang West Rd, Lanzhou 730030, Gansu, Peoples R China;[3]Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Peoples R China;[4]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Peoples R China;[5]Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, 204 Donggang West Rd, Lanzhou 730030, Gansu, Peoples R China.

年份：2025

卷号：178

外文期刊名：SURGERY

收录：;Scopus(收录号：2-s2.0-85210533693);WOS:【SCI-EXPANDED(收录号:WOS:001407171700001)】；

基金：This work was supported by the Health Commission of Gansu Province (GSWSQNPY2024-01) , the First Batch of Longyuan Youth Talent Project in Gansu Province (001,068,001) , the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (NHCDP2022028) , Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province (2020GSZDSYS02) , Research Fund project of Gansu Provincial Hospital (22GSSYC-1, 22GSSYB-14) , and Key Laboratory of Dunhuang Medicine, Ministry of Education (DHYX22-02) .

语种：英文

摘要：Peritoneal adhesion is a common complication of abdominal and pelvic surgery that can cause various clinical symptoms, including abdominal pain, intestinal obstruction, and female infertility, significantly impacting patient quality of life. Animal models of peritoneal adhesion are important tools for studying the mechanisms of adhesion formation and evaluating the effectiveness of prevention and treatment. Various methods for constructing animal models of peritoneal adhesion include physical injury, chemical injury, ischemia, infection, foreign body stimulation, and simulated surgery; however, none can fully simulate peritoneal adhesion in patients clinically. Therefore, this review aimed to explore previous methods used to construct peritoneal adhesion animal models and summarize their principles, characteristics, and applications. Similarly, it summarizes macroscopic and microscopic evaluation indicators, such as peritoneal adhesion gross assessment, histological scoring, and molecular markers. On the basis of this, we proposed a new animal model of peritoneal adhesion that simulates the factors contributing to peritoneal adhesion formation in clinical surgery. peritoneal adhesion formation was stable and standardized using our proposed model, providing a foundation for the establishment and application of peritoneal adhesion animal models. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.