文献类型：期刊文献

英文题名：(+/-)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1

作者：Wu, Jun-Chen[1];Hou, Yanan[1];Xu, Qianhe[1];Jin, Xiao-Jie[2];Chen, Yaxiong[3];Fang, Jianguo[1];Hu, Burong[3];Wu, Quan-Xiang[1]

第一作者：Wu, Jun-Chen

通信作者：Wu, QX[1]

机构：[1]Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[3]Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：21

期号：5

起止页码：1551

外文期刊名：ORGANIC LETTERS

收录：;Scopus(收录号：2-s2.0-85062342008);WOS:【SCI-EXPANDED(收录号:WOS:000460491700067)】；

基金：This work was financially supported by the Program for National Natural Science Foundation (No. 21672087). We thank Prof. Juling Shi (College of Food Science and Engineering, Northwest A&F University, P.R. China) for presenting the fungi and Prof. Yan-Long Yang (State Key Laboratory of Applied Organic Chemistry, Lanzhou University, P.R. China) for designing the proposed biosynthetic pathways.

语种：英文

摘要：A pair of enantiomeric polyketides, (+)- and (-)-alternamgin (1), featuring an unprecedented 6/6/6/6/5/6/6 seven ring backbone, were isolated from the endophytic fungi Alternaria sp. MG1. The relative configuration of 1 was determined using X-ray diffraction, and the absolute configurations of (+/-)-1 were confirmed by comparing the experimental and calculated ECD data. Plausible biosynthetic pathways for 1 were proposed. Compound (-)-I exhibited moderate necrosis rates to Hela and HepG2 cells, but (+)-1 only showed similar necrosis rates to HepG2 cells.