文献类型：期刊文献

中文题名：柴胡及其活性成分防治抑郁症的研究进展

英文题名：Research progress on Bupleuri Radix and its active components in prevention and treatment of major depressive disorder

作者：张茹[1];索欣[1];刘文蓉[1];李英梅[1];王水香[1];窦霞[2];杨新荣[2];靳子明[2]

第一作者：张茹

机构：[1]甘肃中医药大学药学院,兰州730000;[2]甘肃中医药大学附属医院,兰州730020

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2026

卷号：35

期号：11

起止页码：1161

中文期刊名：中国新药杂志

外文期刊名：Chinese Journal of New Drugs

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(82360944);甘肃省中医药科研课题资助项目(GZKZ-2025-34);甘肃省自然科学基金青年科技项目(23JRRA1586);甘肃省药品监督管理局青年科技创新项目(2023GSMPA028);甘肃省中医药研究中心专项开放课题资助项目(zyzx-2025-zx14)。

语种：中文

中文关键词：柴胡;抑郁症;皂苷类;下丘脑-垂体-肾上腺轴;神经递质;神经炎症反应;肠-脑轴

外文关键词：Bupleuri Radix;major depressive disorder;Saponins;HPA axis;Neurotransmitters;Neuroinflammatory response;Gut-brain axis

摘要：抑郁症(major depressive disorder,MDD)是一种以持续心境低落为主要特征的常见精神障碍,患病率高,已成为导致全球疾病负担的主要原因之一。目前临床治疗MDD以西药为主,但存在不良反应频发、复发率高等问题。中医药凭借多靶点、多通路及不良反应少的优势,在MDD治疗中展现出独特的优势。柴胡(Bupleuri Radix)作为中医疏肝解郁要药,具有疏散退热、疏肝解郁、升举阳气等功效,其在MDD防治中的作用近年来受到广泛关注。本文系统梳理近年来柴胡抗抑郁相关研究,明确柴胡中皂苷类、黄酮类及挥发油类成分为核心抗抑郁活性成分,其作用机制主要涉及调节神经递质平衡、改善下丘脑-垂体-肾上腺轴功能紊乱、保护神经可塑性、抑制神经炎症、调控“微生物-肠-脑轴”及抗氧化应激等。本文从柴胡抗抑郁活性成分、作用机制及复方应用3个方面展开综述,为柴胡及其活性成分的开发利用与临床应用提供参考依据。
Major depressive disorder(MDD)is a common psychiatric disorder characterized primarily by persistent low mood.With a high global prevalence,it has become one of the leading causes of the global disease burden.Current clinical treatment for MDD primarily relies on Western medicine,but issues such as frequent adverse reactions and high recurrence rates persist.Traditional Chinese medicine(TCM),leveraging its advantages of multi-target,multi-pathway action and fewer adverse reactions,demonstrates unique potential in MDD treatment.Bupleuri Radix(Chai Hu),a key herb in TCM for soothing the liver and resolving depression,possesses effects such as dispersing heat,soothing the liver and resolving depression,and elevating yang qi.Its role in the prevention and treatment of MDD has garnered significant attention in recent years.This paper systematically reviews recent studies on Bupleuri Radix's antidepressant effects,identifying saponins,flavonoids,and volatile oils as its core active components.Its mechanisms primarily involve regulating neurotransmitter balance,improving hypothalamic-pituitary-adrenal(HPA)axis dysfunction,protecting neural plasticity,suppressing neuroinflammation,modulating the“microbiome-gut-brain axis,”and counteracting oxidative stress.This review covers Bupleuri Radix's active antidepressant components,mechanisms of action,and compound applications,providing a reference for the development,utilization,and clinical application of Bupleuri Radix and its active constituents.