文献类型：期刊文献

英文题名：Maternal calcium, phosphorus, and supplement intake before and during pregnancy and their association with preterm birth risk: based on a large cohort study

作者：Wang, Zifu[1,4];Cao, Lei[1];Li, Yuqing[1];Tian, Qinqin[1];Yang, Chenyan[1];Fu, Hongchuan[1];Fang, Yue[2];Mao, Baohong[3];Yang, Liping[1,4]

第一作者：Wang, Zifu

通信作者：Yang, LP[1];Fang, Y[2];Mao, BH[3];Yang, LP[4]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Dept Planning & Dev, Lanzhou 730050, Gansu, Peoples R China;[3]Gansu Prov Matern & Child Care Hosp, Gansu Prov Cent Hosp, Dept Med Educ, Lanzhou 730050, Gansu, Peoples R China;[4]Gansu Prov Hosp Tradit Chinese Med, Dept Med Qual Control, Lanzhou 730050, Gansu, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Planning & Dev, Lanzhou 730050, Gansu, Peoples R China;[3]corresponding author), Gansu Prov Matern & Child Care Hosp, Gansu Prov Cent Hosp, Dept Med Educ, Lanzhou 730050, Gansu, Peoples R China;[4]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Med Qual Control, Lanzhou 730050, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2026

卷号：45

期号：1

外文期刊名：JOURNAL OF HEALTH POPULATION AND NUTRITION

收录：;Scopus(收录号：2-s2.0-105029136660);WOS:【SCI-EXPANDED(收录号:WOS:001678182800002)】；

基金：This work was supported in part by Gansu Provincial Health Commission Research Project (No.GSWSKY2024-14; No.GSWSKY2024-49), and the Traditional Chinese Medicine Management Project of Gansu Province (No.GZKG-2024-43).

语种：英文

外文关键词：Calcium; Phosphorus; Calcium supplement; Intake; Pregnancy; Preterm birth

摘要：BackgroundPreterm birth (PTB) is a global epidemic, defined as delivery before 37 weeks of gestation, and is an important risk factor for neonatal death, morbidity and abnormal childhood development. Premature birth is currently regarded as a complex disease influenced by multiple factors. Common risk factors include nutritional deficiency during pregnancy, maternal obesity, environmental exposure, infection and inflammation, among which maternal nutrition during pregnancy is an important modifiable factor.ObjectiveTo assess the relationship between maternal dietary calcium, phosphorus intake, and calcium supplement use before and during pregnancy was associated with the risk of PTB in offspring.MethodThis study was a nested case-control study conducted based on a large cohort study. And included pregnant women who were registered at the Perinatal Medicine Center of Gansu Provincial Maternal and Child Health Hospital from March 2018 to March 2019 and whose birth outcomes could be followed up. One-on-one dietary interviews were conducted during pregnancy, and a database was established based on the overall dietary intake levels for subsequent statistical analysis. PTB was defined as the outcome variable, while the intake levels of different substances during pregnancy were set as independent variables. Unconditional logistic regression models estimated the association between nutrient intake and the risk of PTB. Calculating the odds ratio (OR) and its 95% confidence interval (CI) to analyze the impact of different substance intake levels on PTB. Additionally, a restricted cubic spline (RCS) model with multivariable adjustment was applied to excess the non-linear association between dietary magnesium and calcium intake was associated with the risk of PTB.ResultA total of 8897 pregnant women were included in the study, with 880 assigned to the case group and 8017 to the control group. Multivariate logistic regression analysis showed that low phosphorus intake in the second trimester was associated with an increased risk of PTB (OR = 1.297, CI: 1.020-1.649, P = 0.0341). Furthermore, similar results also exist for non-use of calcium supplements during the third trimester and low calcium intake preconception and during pregnancy. In addition, calcium, phosphorus and calcium supplements have a synergistic effect was associated with the risk of PTB.ConclusionDuring the second and third trimesters of pregnancy, the intake of phosphorus and the use of calcium supplements should be increased. Additionally, to prevent premature birth, the intake of calcium should be increased preconception and during pregnancy. Furthermore, this might lead to the optimization of public health policies or the formulation of guidelines for prenatal nutrition.