文献类型：期刊文献

中文题名：中药通过AMPK途径对糖尿病致内皮功能障碍的保护作用及机制

英文题名：Protective Effect and Mechanism of Chinese Medicine on Endothelial Cell Dysfunction Induced by Diabetes Mellitus Through AMPK Pathway

作者：武兵兵[1];马礼科[3];刘秀珠[1];张爱平[1];赵信科[2];刘凯[1,2]

第一作者：武兵兵

机构：[1]甘肃中医药大学中西医结合学院,兰州730000;[2]甘肃中医药大学附属医院心血管内科,兰州730000;[3]甘肃省庄浪县中医医院心血管内科,庄浪744699

第一机构：甘肃中医药大学中西医结合学院

年份：2022

卷号：38

期号：3

起止页码：225

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家中医药管理局国家中医药循证能力建设项目(编号:2019XZZX-XXG002);甘肃省中医药研究中心开放课题(编号:ZYZX-2020-16);甘肃省自然科学基金(编号:21JR7RA562)

语种：中文

中文关键词：中药;糖尿病;内皮功能障碍;腺苷酸活化蛋白激酶

外文关键词：Traditional Chinese medicine;Diabetes mellitus;Endothelial cell dysfunction;AMPK

摘要：内皮细胞功能障碍(ECD)在糖尿病血管病变的发展中起着关键作用。腺苷酸活化蛋白激酶(AMPK)途径参与降糖、改善胰岛素抵抗、稳定糖脂代谢、减轻炎症和氧化应激等,在糖尿病致血管内皮细胞功能障碍中发挥重要的保护作用,可能成为新的治疗靶点。药用植物是天然强效抗糖尿病药物的基本来源,除了降血糖作用外,临床研究中药配方及其成分还能增强内皮功能和抗动脉粥样硬化,但其机制并不完全清楚。因此本文就中药、配方及其成分如何通过AMPK途径降糖、抗氧化应激、抗炎、降低脂毒性及改善胰岛素抵抗等来保护血管内皮功能进行综述,以期为开发和防治糖尿病血管并发症奠定基础。
Endothelial cell dysfunction(ECD)plays a key role in the development of diabetic vascular disease.The adenosine monophosphate-activated protein kinase(AMPK)pathway is involved in lowering blood glucose,improving insulin resistance,stabilizing glucose and lipid metabolism,reducing inflammation and oxidative stress,etc.It plays an important protective role against ECD induced by diabetes mellitus and may serve as a new therapeutic target.Medicinal plants are the basic sources of natural potent anti-diabetic drugs.In addition to their hypoglycemic function,Chinese medicinal formulations and their components have been clinically verified to enhance endothelial function and resist atherosclerosis,but the mechanisms remain unclear.The present study reviewed how Chinese medicine,Chinese medicinal formulations,and their components protect vascular endothelial function through the AMPK pathway by lowering blood glucose,resisting oxidative stress and inflammation,reducing lipid toxicity,and improving insulin resistance to provide a basis for preventing diabetic vascular complications and developing of new drugs.