文献类型：期刊文献

中文题名：幽门螺杆菌感染率和复发率的年龄及性别差异

英文题名：Age and gender differences in Helicobacter pylori infection and recurrence rates

作者：乔玉琴[1];周芸[1,2];赵丽[3];张小冬[4];杨胜毅[5];曹轶博[6];白录目草[1];刘世雄[1,2]

第一作者：乔玉琴

机构：[1]兰州大学第一临床医学院,甘肃兰州730000;[2]兰州大学第一医院老年医学科;[3]甘肃中医药大学附属医院超声科;[4]张掖市第二人民医院重症医学科;[5]天水市中西医结合医院重症医学科;[6]锡林郭勒盟中心医院老年医学科/全科医学科

第一机构：兰州大学第一临床医学院,甘肃兰州730000

年份：2025

卷号：34

期号：8

起止页码：1134

中文期刊名：胃肠病学和肝病学杂志

外文期刊名：Chinese Journal of Gastroenterology and Hepatology

基金：甘肃省科技计划项目(重点研发计划)(21YF5FA120);甘肃卫生行业科研计划项目(GSWSKY2020-12)。

语种：中文

中文关键词：幽门螺杆菌;性别;年龄;根除;复发

外文关键词：Helicobacter pylori;Gender;Age;Eradication;Recurrence

摘要：目的比较健康体检人群幽门螺杆菌(Helicobacter pylori,H.pylori)感染率和1年复发率的年龄、性别差异。方法对兰州大学第一医院体检中心一部和二部、甘肃中医药大学附属医院、甘肃张掖市第二人民医院、甘肃天水市中西医结合医院2010年3月至2019年12月81754例健康体检人群H.pylori感染情况进行横断面研究,男53771例(65.77%),年龄18~91岁,女27983例(34.23%),年龄18~94岁。按年龄分为青年组(包括18~<25岁、25~<30岁、30~<35岁和35~<40岁年龄段),中年组(包括40~<45岁、45~<50岁、50~<55岁和55~<60岁年龄段)和老年组(包括60~<65岁、65~<70岁、70~<75岁和≥75岁年龄段)。选取1448例无症状感染者进行2周含铋剂四联药物根除治疗,比较男、女根除率和1年后复发率。结果体检人群总体感染率为49.59%,男性为49.74%,女性为49.3%。青年组女性感染风险低于男性(OR=0.908,95%CI:0.868~0.95,P<0.01),老年组女性感染风险高于男性(OR=1.137,95%CI:1.041~1.243,P<0.01)。女性感染率与年龄段呈线性正相关,Spearman相关系数为0.825(P<0.01)。总体根除率按意向治疗(intention-to-treat,ITT)分析为84.67%,按符合方案(per-protocol,PP)分析为88.46%,各年龄组间比较差异均无统计学意义。老年组女性根除率ITT和PP分别为78.38%和82.27%,低于男性组的87.25%和89.39%(P<0.05)。1年总体复发率为3.86%,其中男性为2.82%,女性为5.44%(P<0.05),控制年龄因素后女性是根除后复发的一个危险因素(OR=2.177,95%CI:1.166~4.066,P<0.05)。结论女性H.pylori感染率与年龄增加呈线性正相关,老年女性具有H.pylori感染率高、根除率低、复发率高的特点。
Objective To compare age and gender differences in Helicobacter pylori(H.pylori)infection rates and 1-year recurrence rates in a healthy physical examination population.Methods A cross-sectional study was conducted on H.pylori infection in 81754 cases of health checkups from Mar.2010 to Dec.2019 in the First Hospital of Lanzhou University Physical Examination Center Part Ⅰ and Part Ⅱ,the Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Zhangye Second People's Hospital and Tianshui Combine Traditional Chinese and Western Medicine Hospital,in which there were 53771 cases(65.77%)of males aged 18-91 years old,females 27983 cases(34.23%),aged 18-94 years old.They were categorized into young age group(including 18-<25,25-<30,30-<35 and 35-<40 years old groups),middle age group(including 40-<45,45-<50,50-<55 and 55-<60 years old groups)and old age group(including 60-<65,65-<70,70-<75 and≥75 years old groups)according to their age.A total of 1448 asymptomatic infections were selected for 2-week bismuth-containing quadruple drug eradication treatment,and eradication rates and recurrence rates at 1 year were compared between males and females.Results The overall infection rate of the medical examination population was 49.59%,including 49.74% for males and 49.3% for females.The risk of infection was lower in females than in males in the young group(OR=0.908,95%CI:0.868-0.95,P<0.01)and higher in females than in males in the older group(OR=1.137,95%CI:1.041-1.243,P<0.01).Infection rates in females were linearly and positively correlated with age group,with a Spearman correlation coefficient of 0.825(P<0.01).Overall eradication rate was 84.67%analyzed by intention-to-treat(ITT)analysis and 88.46% analyzed by per-protocol(PP)analysis,and comparisons between age groups were not significant.The eradication rates ITT and PP were 78.38% and 82.27%in the older age group for females,which were lower than those of 87.25% and 89.39% in the male group,respectively(P<0.05).The overall recurrence rate at 1 year was 3.86%,with 2.82% in males versus 5.44% in females(P<0.05),and controlling for age,females were a risk factor for post-eradication recurrence(OR=2.177,95%CI:1.166-4.066,P<0.05).Conclusion There is a positive linear correlation between H.pylori infection rate and age increase in females.Elderly females have the characteristics of high H.pylori infection rate,low eradication rate and high recurrence rate.