文献类型：期刊文献

中文题名：疏肝汤联合米氮平对肝郁化火型失眠患者的临床疗效

英文题名：Clinical effects of Shugan Decoction combined with mirtazapine on insomnia patients due to Liver Depression Transforming into Fire

作者：赵剑华[1];黄生辉[2];彭晓明[1];张震文[1];王晋阳[1];刘敏科[2];张静霞[1]

第一作者：赵剑华

机构：[1]甘肃中医药大学附属医院脑病科,甘肃兰州730020;[2]甘肃中医药大学附属医院神经内科,甘肃兰州730020

第一机构：甘肃中医药大学第二附属医院

年份：2019

卷号：41

期号：5

起止页码：1036

中文期刊名：中成药

外文期刊名：Chinese Traditional Patent Medicine

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：甘肃省中医药管理局(GZK-2018-19);甘肃中医药大学附属医院院内课题(gzfy-2017-03)

语种：中文

中文关键词：疏肝汤;米氮平;失眠;肝郁化火

外文关键词：Shugan Decoction;mirtazapine;insomnia;Liver Depression Transforming into Fire

摘要：目的探讨疏肝汤联合米氮平对肝郁化火型失眠患者的临床疗效。方法 118例患者随机分为对照组(56例)和观察组(62例),对照组给予米氮平,观察组在对照组基础上加用疏肝汤,8周为1个疗程。然后,检测临床疗效,中医症候评分,下丘脑-垂体-靶腺轴激素(TSH、TRH、GH、Cor、FT4)水平,匹兹堡睡眠质量指数量表(PSQI)评分,焦虑、抑郁评分,生活质量评分,不良反应发生率变化。结果观察组总有效率显著高于对照组(P<0.05)。治疗后,2组中医症候评分,下丘脑-垂体-靶腺轴激素水平,PSQI评分,焦虑、抑郁评分显著降低(P<0.05),生活质量评分显著升高(P<0.05),以观察组更明显(P<0.05),不良反应发生率无显著差异(P>0.05)。结论疏肝汤联合米氮平可调节肝郁化火型失眠患者下丘脑-垂体-靶腺轴激素表达,改善睡眠质量和生活质量,安全性较高,临床疗效良好。
AIM To explore the clinical effects of Shugan Decoction combined with mirtazapine on insomnia patients due to Liver Depression Transforming into Fire.METHODS One hundred and eighteen patients were randomly divided into control group(56 cases)for 8-week administration of mirtazapine,and observation group(62 cases)for 8-week administration of Shugan Decoction and mirtazapine.Subsequently,the changes in clinical efficacy,TCM symptom score,levels of hypothalamus-pituitary-target gland axis hormones(TSH,TRH,GH,Cor,FT4),Pittsburgh sleep quality index scale(PSQI)score,anxiety and depression scores,life quality score,and occurrance rate of adverse reactions were detected.RESULTS The observation group demonstrated significantly higher total effective rate than the control group(P<0.05).After the treatment,TCM syndrome score,levels of hypothalamic-pituitary-target gland axis hormones,PSQI score,and anxiety and depression scores were markedly decreased(P<0.05)in the two groups with obviously increased life quality score(P<0.05),especially for those in the observation group(P<0.05),and no significant difference in occurrance rate of adverse reactions was found(P>0.05).CONCLUSION For the insomnia patients due to Liver Depression Transforming into Fire,Shugan Decoction combined with mirtazapine can regulate the expressions of hypothalamus-pituitary-target gland axis hormones and improve sleep quality and life quality,with high safety and good clinical efficacy.