文献类型：期刊文献

中文题名：MicroRNA-155对自噬的调节在胃癌诊治中的作用研究进展

英文题名：Research progress in the role of microRNA-155 in regulation of autophagy and diagnosis and treatment for gastric cancer

作者：陈刚[1,2];张敏敏[3];李玉民[1,2]

第一作者：陈刚

机构：[1]甘肃省消化系肿瘤重点实验室,兰州730030;[2]兰州大学第二医院普外一科,兰州730030;[3]甘肃中医药大学临床医学院,兰州730000

第一机构：甘肃省消化系肿瘤重点实验室,兰州730030

年份：2019

卷号：44

期号：1

起止页码：87

中文期刊名：中南大学学报（医学版）

外文期刊名：Journal of Central South University ：Medical Science

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；PubMed;

基金：国家国际科技合作专项(2015DFA31650)~~

语种：中文

中文关键词：胃癌;microRNA-155;自噬;多药耐药

外文关键词：gastric cancer;microRNA-155;autophagy;multidrug resistance

摘要：我国是全球胃癌高发地区之一,早期检出率低,疗效差,5年存活率低,手术联合放射治疗和化学药物治疗是主流的综合治疗方案,但化学药物治疗多药耐药普遍存在。化学药物治疗、miRNA和自噬三者之间相互影响,但机制复杂。MiR-155在胃癌中表达异常,促进自噬,抑制凋亡,与幽门螺杆菌相互作用诱发胃癌。通过miR-155调节自噬可以用来治疗胃癌,还可用于改善化学药物治疗敏感性以逆转耐药。MiR-155在胃癌组织中的高表达提示预后不良。
China is one of the regions with a high incidence of gastric cancer worldwide.Low detection rate and poor curative eff ect lead to unsatisfi ed prognosis and low five-year survival rate.Surgery combined with radiotherapy and chemotherapy is the mainstream comprehensive treatment scheme,however,multi-drug resistance may gradually prevail in the chemotherapy process.Chemotherapy,miRNA and autophagy interact with each other,but the mechanism is complex.MiR-155 is abnormally expressed in gastric cancer,which could promote autophagy,inhibit apoptosis,and interact with Helicobacter pylori to induce gastric cancer.Through its regulatory eff ect on autophagy,miR-155 can be used to treat gastric cancer,improve chemotherapy sensitivity and reverse drug resistance.The high expression of miR-155 in gastric cancer tissues suggests poor prognosis.