文献类型：期刊文献

英文题名：Metabolomics combined with network pharmacology reveals the potential development value of Campanumoea javanica Bl. and its metabolite differences with Codonopsis Radix

作者：Peng, Jie[1,2];Liu, Sha[2,4];Wu, Xuanlin[2];Li, Shuo[3];Xie, Jian[2];Wang, Yong[4];Yao, Qiuyang[2];Wu, Faming[1,2,5];Zhang, Delin[1,2]

第一作者：Peng, Jie

通信作者：Wu, FM[1];Zhang, DL[1];Wu, FM[2];Zhang, DL[2];Wu, FM[3]

机构：[1]Zunyi Med Univ, Affiliated Hosp, Clin Pharm, Zunyi 563003, Peoples R China;[2]Zunyi Med Univ, Sch Pharm, Zunyi 563000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[4]Guizhou Med & Hlth Ind Res Inst, Zunyi 563000, Peoples R China;[5]Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550000, Peoples R China

第一机构：Zunyi Med Univ, Affiliated Hosp, Clin Pharm, Zunyi 563003, Peoples R China

通信机构：[1]corresponding author), Zunyi Med Univ, Affiliated Hosp, Clin Pharm, Zunyi 563003, Peoples R China;[2]corresponding author), Zunyi Med Univ, Sch Pharm, Zunyi 563000, Peoples R China;[3]corresponding author), Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550000, Peoples R China.

年份：2024

卷号：24

期号：1

外文期刊名：BMC PLANT BIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001271997500001)】；

基金：Not applicable.DAS:The data supporting the fndings of this study are available from the corresponding author, W.F. (wufaming@zmu.edu.cn), upon request.

语种：英文

外文关键词：Campanumoea javanica Bl.; Codonopsis radix; Metabolite; Widely targeted metabolomics; Network pharmacology

摘要：Campanumoea javanica Bl. (CJ) traditionally used in Southwestern China, is now widely consumed as a health food across the nation. Due to its similar efficacy to Codonopsis Radix (CR) and their shared botanical family, CJ is often used as a substitute for CR. According to the Chinese Pharmacopoeia, Codonopsis pilosula var. modesta (Nannf.) L.T. Shen (CPM), Codonopsis pilosula (Franch.) Nannf. (CP), and Codonopsis tangshen Oliv. (CT) are the primary sources of CR. However, details on the differences in composition, effectiveness, and compositional between CJ and CR are still limited. Besides, there is little evidence to support the application of CJ as a drug. In this study, we employed widely targeted metabolomics, network pharmacology analysis, and molecular docking to explore the disparities in metabolite profiles between CJ and CR and to predict the pharmacological mechanisms of the dominant differential metabolites of CJ and their potential medicinal applications. The widely targeted metabolomics results indicated that 1,076, 1,102, 1,102, and 1,093 compounds, most phenolic acids, lipids, amino acids, and flavonoids, were characterized in CJ, CPM, CP, and CT, respectively. There were an average of 1061 shared compounds in CJ and CRs, with 95.07% similarity in metabolic profiles. Most of the metabolites in CJ were previously unreported. Twelve of the seventeen dominant metabolites found in CJ were directly associated with treating cancer and lactation, similar to the traditional medicinal efficacy. The molecular docking results showed that the dominant metabolites of CJ had good docking activity with the core targets PIK3R1, PIK3CA, ESR1, HSP90AA1, EGFR, and AKT1. This study provides a scientific basis for understanding the similarities and differences between CJ and CR at the metabolome level, offering a theoretical foundation for developing innovative medications from CJ. Additionally, it significantly enhances the metabolite databases for both CJ and CR.