文献类型：期刊文献

中文题名：中医药调控内质网应激治疗骨质疏松症的研究现状

英文题名：Research status of traditional Chinese medicine regulating endoplasmic reticulum stress in the treatment of osteoporosis

作者：曹婷婷[1];白敏[2];汪湛东[3];闫丰喆[4];宋文静[1];郭超[1,2,3,4,5];汪永锋[6];宋冰[1,2,3,4,5];张延英[1,2,3,4,5]

第一作者：曹婷婷

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]甘肃中医药大学基础医学院,甘肃兰州730000;[3]甘肃中医药大学中西医结合学院,甘肃兰州730000;[4]甘肃中医药大学中医临床学院,甘肃兰州730000;[5]甘肃省实验动物行业技术中心,甘肃兰州730000;[6]甘肃医学院基础医学院,甘肃平凉744000

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：40

期号：24

起止页码：3643

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：甘肃省科技重点研发计划基金资助项目(23YFFA0068);甘肃省教育厅高等学校科研基金资助项目(2023A-080);甘肃省中医药管理局基金资助项目(GZKP-2023-19);甘肃中医药大学成果转化培育基金资助项目(2023CGZH-21);甘肃省中医药大学研究生创新创业基金资助项目。

语种：中文

中文关键词：中医药;骨质疏松症;内质网应激;成骨细胞;破骨细胞;间充质干细胞

外文关键词：traditional Chinese medicine;osteoporosis;endoplasmic reticulum stress;osteoblast;osteoclast;mesenchymal stem cells

摘要：骨质疏松症(OP)是骨吸收与骨形成失衡的一类骨相关疾病。研究发现,内质网应激(ERS)在OP发病机制中起着重要作用,一方面适度的ERS能够通过多种信号通路调控间充质干细胞、成骨细胞和破骨细胞分化促进骨平衡稳态;另一方面过度的ERS通过多种途径诱导骨相关细胞凋亡破坏骨平衡稳态。中药单体及复方对于OP的治疗效果显著。研究发现,调控ERS是中医药有效治疗OP的重要机制之一。本文通过分析汇总近年来国内外文献,就ERS进程参与骨质疏松症的相关研究及中医药针对ERS进程治疗OP的研究进行综述,为进一步揭示ERS进程参与OP的发病机制以及为中医药的调控作用提供依据。
Osteoporosis(OP)is a bone-related disease characterized by an imbalance between bone resorption and bone formation.Recent studies have shown that endoplasmic reticulum stress(ERS)plays an important role in the pathogenesis of OP.On the one hand,moderate ERS can regulate the differentiation of mesenchymal stem cells,osteoblasts and osteoclasts through multiple signaling pathways to promote bone homeostasis.On the other hand,excessive ERS can induce apoptosis of bone-related cells through various ways to disrupt bone homeostasis.Traditional Chinese medicine monomer and compound have significant therapeutic effect on OP.Recent studies have found that regulating ERS is one of the important mechanisms of effective treatment of OP by traditional Chinese medicine.From the perspective of ER stress,many studies have explored the mechanism of action in the treatment of OP by Chinese medicine.In this paper,through analyzing and summarizing the literature at home and abroad in recent years,the relevant studies on the involvement of ERS process in osteoporosis and the studies on the treatment of OP by Chinese medicine ERS process were reviewed.To further reveal the involvement of ERS process in the pathogenesis of osteoporosis and the regulatory role of traditional Chinese medicine.