文献类型：期刊文献

英文题名：Regulated Cell Death and Inflammatory Signaling in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Strategies

作者：Lu, Yuyuan[1];Cui, Jia[1];Cheng, Xueyan[1];Li, Jiawei[1];Zhang, Lingna[1];Tian, Jiao[1];Yang, Ani[2];Yi, Lin[1,3]

第一作者：Lu, Yuyuan

通信作者：Yi, L[1];Yang, AN[2];Yi, L[3]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Dept Cardiovasc Med, Lanzhou 730050, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Chron Dis Lab, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Cardiovasc Med, Lanzhou 730050, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Tradit Chinese Med, Chron Dis Lab, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

外文期刊名：JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH

收录：;Scopus(收录号：2-s2.0-105019772104);WOS:【SCI-EXPANDED(收录号:WOS:001597821700001)】；

基金：This work was supported by grants from the National Natural Science Foundation of China, No. 82160842; Traditional Chinese Medicine scientific research Project in Gansu Province in 2023, No. GZKP-2023-40; Open Subjects of Dunhuang Medicine in the Key Laboratory of Translation of the Ministry of Education, No. DHYX23-07; General Program of the Joint Scientific Research Fund, No. 23JRRA1521; 2025 "Innovation and Entrepreneurship Fund" project for graduate students of Gansu University of Traditional Chinese Medicine, NO. 2025CXCY-012.

语种：英文

外文关键词：Diabetic cardiomyopathy; Cell death; Inflammatory signaling; Therapeutic strategies

摘要：Diabetic cardiomyopathy (DCM) is a common complication of diabetes, characterized by myocardial injury, fibrosis, and heart dysfunction. The pathogenesis remains poorly understood, with limited treatment options. Recent research highlights the roles of regulated cell death (RCD) and inflammation in DCM progression. RCD types, including apoptosis, pyroptosis, ferroptosis, and necroptosis, are central to myocardial damage and are closely linked to oxidative stress and inflammation. Inflammatory pathways like NLRP3, NF-kappa B, and TLR4 activate cytokines (TNF-alpha, IL-1 beta, IL-6), exacerbating fibrosis and heart failure. Notably, RCD and inflammation create a feedback loop, amplifying each other and accelerating DCM. This review explores the interactions between RCD and inflammatory signaling, their contribution to myocardial injury, and potential therapeutic strategies targeting both pathways. A multi-targeted approach to DCM therapy may offer new avenues for treatment.