文献类型：期刊文献

中文题名：肿瘤相关巨噬细胞在胃癌中的研究进展

英文题名：Research Progress of Tumor-Associated Macrophages in Gastric Cancer

作者：仝建宁[1];呼永华[1,2,3];陈昊[3];王晓宇[1];周浩楠[1]

第一作者：仝建宁

机构：[1]甘肃中医药大学第一临床医学院,甘肃 兰州;[2]甘肃中医药大学附属医院肿瘤科,甘肃 兰州;[3]兰州大学第二临床医学院,甘肃 兰州

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：13

期号：4

起止页码：5236

中文期刊名：临床医学进展

外文期刊名：Advances in Clinical Medicine

语种：中文

中文关键词：肿瘤相关巨噬细胞;胃癌;免疫微环境

摘要：肿瘤相关巨噬细胞在不同因子的作用下可以分化为经典活化型和交替活化型两种表型,两种表型对胃癌细胞的发生、发展发挥相反的作用,其中,M2型能够分泌多种趋化因子,抑制炎性反应的发生,促进血管和淋巴管形成。胃癌是常见的恶性消化道肿瘤,患者整体生存率还较低,因此寻找特异性的能够预测预后的因素,开发新的作用靶点迫在眉睫。鉴于此本文就肿瘤相关巨噬细胞在胃癌中的有关研究进行分析、综述,以期为改善胃癌患者预后,研发新型靶向药物提供新视角。
Tumor-associated macrophages can differentiate into two phenotypes, classical activation and al-ternating activation under the action of different factors, and the two phenotypes play opposite roles on the occurrence and development of gastric cancer cells, among which M2 can secrete a va-riety of chemokines, inhibit the occurrence of inflammatory reactions, and promote the formation of blood vessels and lymphatic vessels. Gastric cancer is a common malignant digestive tract tumor, and the overall survival rate of patients is still low, so it is urgent to find specific factors that can predict prognosis and develop new targets. In view of this, this paper analyzes and reviews the rel-evant research of tumor-associated macrophages in gastric cancer, in order to provide a new per-spective for improving the prognosis of gastric cancer patients and developing new targeted drugs.