文献类型：期刊文献

中文题名：姜石颗粒联合微生态制剂治疗肠易激综合征腹泻型脾虚湿盛证30例临床观察

英文题名：Clinical observation on 30 cases of diarrhea-predominant irritable bowel syndrome with superabundance of dampness due to spleen deficiency symptom treated by Jiangshi Keli(姜石颗粒)combined with microecological preparation

作者：符博雅[1];刘俊宏[2];郑敏[2];王淼蕾[1];牛媛媛[3]

第一作者：符博雅

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730101;[2]甘肃中医药大学附属医院脾胃病科,甘肃兰州730020;[3]甘肃中医药大学中医临床学院,甘肃兰州730101

第一机构：甘肃中医药大学中西医结合学院

年份：2022

卷号：39

期号：2

起止页码：47

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：国家自然科学基金地区基金项目(81660773);国家中医药管理局基金项目--国医大师周信有传承工作室(国中医药规财发[2017]28号);敦煌医学与转化教育部重点实验室开放基金项目(DHYX18-14);甘肃省中医药管理局科研项目(GZK-2018-15)。

语种：中文

中文关键词：肠易激综合征腹泻型;脾虚湿盛证;姜石颗粒;微生态制剂;中医症状积分;肠道敏感性状况评分;临床疗效;

外文关键词：diarrhea-predominant irritable bowel syndrome(IBS-D);superabundance of dampness due to spleen deficiency symptom;Jiangshi Keli(姜石颗粒);microecological preparation;TCM symptom scores;enteric sensitivity score;clinical efficacy;

摘要：目的观察姜石颗粒联合微生态制剂治疗肠易激综合征腹泻型(IBS-D)脾虚湿盛证的临床疗效及对肠道敏感性的影响。方法选取甘肃中医药大学附属医院脾胃病科住院治疗的IBS-D脾虚湿盛证患者60例,采用随机数字表法分为治疗组和对照组,各30例。对照组给予微生态制剂治疗,治疗组在对照组治疗方法的基础上联合姜石颗粒治疗,2组均以14 d为1个疗程,治疗2个疗程后比较2组的临床疗效、不良反应发生情况以及治疗前后的中医症状积分、肠道敏感性状况评分。结果治疗后治疗组各项中医症状(腹痛、腹泻、神疲、纳少、四肢倦怠、便溏)积分及肠道敏感性状况评分明显降低,对照组除腹痛积分外,其他中医症状积分及肠道敏感性状况评分均明显降低,与同组治疗前比较差异均有统计学意义(P<0.05),且治疗组腹痛、腹泻、神疲等中医症状积分及肠道敏感性状况评分降低更明显,与对照组治疗后比较差异均有统计学意义(P<0.05);治疗组总有效率为93.4%(28/30),对照组为70.0%(21/30),2组比较差异有统计学意义(P<0.05)。结论姜石颗粒联合微生态制剂可明显改善IBS-D脾虚湿盛证患者的临床症状及肠道敏感状况,临床疗效显著,且无明显不良反应。
Objective To observe the clinical efficacy of Jiangshi Keli(姜石颗粒)combined with microecological preparation in the treatment of diarrhea-predominant irritable bowel syndrome(IBS-D)with superabundance of dampness due to spleen deficiency symptom and its effects on enteric sensitivity.Methods Sixty IBS-D patients with superabundance of dampness due to spleen deficiency symptom hospitalized in the department of spleen and stomach diseases of the Affiliated Hospital of Gansu University of Chinese Medicine were divided into treatment group and control group according to random number table method,with 30 cases in each group.The control group was given microecological preparation,on this basis,the treatment group was combined with Jiangshi Keli.Both groups took 14 days as 1 course of treatment.After 2 courses of treatment,the clinical efficacy,incidence of adverse reactions,TCM symptom scores and enteric sensitivity scores before and after treatment between the 2 groups were compared.Results After treatment,the scores of various TCM symptoms(abdominal pain,diarrhea,mental fatigue,reduced food intake,lassitude of limbs,loose stool)and enteric sensitivity in the treatment group decreased significantly.Except the abdominal pain score,the other TCM symptom scores and enteric sensitivity scores in the control group were significantly lower than those in the same group before treatment(P<0.05),moreover,the scores of TCM symptoms such as abdominal pain,diarrhea and mental fatigue and the score of enteric sensitivity in the treatment group decreased more significantly,and the difference was statistically significantly lower than that in the control group after treatment(P<0.05).The total effective rate was 93.4%(28/30)in the treatment group and 70.0%(21/30)in the control group,and the difference was statistically significant between the 2 groups(P<0.05).Conclusion Jiangshi Keli combined with microecological preparation can markedly improve the clinical symptoms and enteric sensitivity of IBS-D in patients with superabundance of dampness due to spleen deficiency symptom,with marked clinical efficacy and no obvious adverse reactions.