文献类型：期刊文献

中文题名：单叶细辛对家兔肾功能的影响

英文题名：Influence of single leaf Asarum himalaicum on renal function of rabbits

作者：明海霞[1];刘家骏[1];黄世佐[1]

第一作者：明海霞

机构：[1]甘肃中医学院生理学教研室

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

年份：2004

卷号：2

期号：3

起止页码：199

中文期刊名：中西医结合学报

外文期刊名：Journal of Chinese Integrative Medicine

收录：MEDLINE(收录号：15339444);;Scopus;PubMed

基金：甘肃省教育厅科研项目 (No .0 2B4 0 4)

语种：中文

中文关键词：单叶细辛;家兔;肾功能;辽细辛;生理盐水

外文关键词：Asarum himalaicum;Asarum heterotropoides;acute renal failure;animal,laboratory

摘要：目的 :研究单叶细辛对家兔肾功能的影响。方法 :将家兔随机分为单叶细辛组、辽细辛对照组和生理盐水对照组3组 ,分别测定静脉注射药物前后的每分钟尿量、尿液pH值、尿蛋白、尿糖、尿潜血、血尿素氮 (BUN)、血肌酐 (SCr)、血栓素B2(TXB2 )、6 酮 前列腺素F1α(6 keto PGF1α)、TXB2 / 6 keto PGF1α的比值、内皮素 (ET)、对氨基马尿酸清除率及酚红排泄率等指标。结果 :单叶细辛在一定剂量下可导致家兔急性肾衰竭 ,各项指标与生理盐水对照组比较有统计学差异 ;与辽细辛对照组比较 ,各项指标均较低 ,但除SCr外 ,统计学处理无显著性差异。结论 :单叶细辛对家兔肾功能有损害作用 ,但其肾毒性小于辽细辛。
Objective:To study the influence of single leaf Asarum himalaicum on the renal function of rabbits. Methods:Rabbits were divided into three groups. Asarum himalaicum, Asarum heterotropoides and normal saline were intravenously administered to the rabbits of one group respectively. The urine volume per minute, urine pH, urine glucose, protein and red blood cells, BUN,SCr,TXB 2, 6-keto-PGF 1α, TXB 2/6-keto-PGF 1α,endothelin, p-aminohippuric acid clearance rate and phenolsulfonphthalein excretion rate were tested before and after the administration. Results:A certain dosage of single leaf Asarum himalaicum caused acute renal failure in rabbits. The indices tested were significantly diffrent between rabbits administered Asarum himalaicum and normal saline.As compared with the rabbits administered Asarum heterotropoides,the results of indices tested decreased,but without statistical significance,except for SCr.Conclusion:The single leaf Asarum himalaicum can cause renal damage to rabbits.Its renal toxicity is lower that that of Asarum heterotropoides.