文献类型：期刊文献

英文题名：Protective effects of dexmedetomidine against propofol-induced memory impairment in developing rat involved Src and RARα

作者：Xu, Xiaoyan[1];Yang, Jianmei[2];Jia, Qiang[2];Hu, Qianqian[3];Liu, Huiling[4,5]

第一作者：徐晓艳;徐小艳

通信作者：Yang, JM[1]

机构：[1]Gansu Univ Chinese Med, Peoples Hosp Lanzhou City 1, Clin Med Coll 2, Clin Med Coll 1,Dept Obstet & Gynecol, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Peoples Hosp Lanzhou City 1, Clin Med Coll 2, Dept Anesthesiol, 1 West Wujiayuan St, Lanzhou 730050, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Peoples Hosp Lanzhou City 1, Clin Med Coll 2, Dept Obstet & Gynecol, Lanzhou, Peoples R China;[4]Gansu Prov Peoples Hosp, Dept Obstet & Gynecol, Lanzhou, Peoples R China;[5]Gansu Univ Tradit Chinese Med, Clin Sch 1, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Peoples Hosp Lanzhou City 1, Clin Med Coll 2, Dept Anesthesiol, 1 West Wujiayuan St, Lanzhou 730050, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：44

外文期刊名：HUMAN & EXPERIMENTAL TOXICOLOGY

收录：;Scopus(收录号：2-s2.0-105004333261);WOS:【SCI-EXPANDED(收录号:WOS:001478532400001)】；

基金：The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by Science and Technology Plan Project of Lanzhou Science and Technology Bureau, Gansu Province [Project Number: 2023-4-11]. And Supported by Gansu Provincial Science and Technology Plan, Gansu Provincial Natural Science Foundation [Project number: 23JRRA1455, 24JRRA766].

语种：英文

外文关键词：dexmedetomidine; propofol; memory impairment; autophagy; apoptosis

摘要：BackgroundDexmedetomidine (DEX) can offer protection to the nervous, urinary and circulatory systems. It can alleviate local oxidative stress, reduce inflammatory responses, inhibite cellular autophagy and decrease apoptosis.AimTo explore the potential protection and possible mechanisms of DEX against propofol (PPF)-induced memory impairment in developing rats.Material and methodsThe effects of DEX on spatial learning and passive avoidance abilities of rats were evaluated using eight-arm mirror maze and passive avoidance experiments. mRNA levels were detected using RT-qPCR analysis while protein levels were determined using western blot. A network pharmacology approach was used to predict potential targets of DEX against PPF-induced memory impairment. The cell autophagy and apoptosis were detected using commercial kits.ResultsDEX improved the impairment of developing rats on spatial learning and passive avoidance caused by PPF exposure. DEX regulates autophagic activity to inhibit neuronal apoptosis. RAR alpha and Src were potential targets for DEX against memory impairment caused by PPF exposure. DEX upregulated the expression levels of Bdnf, p-CREB/CREB, p-Akt/Akt, and p-TrkB/TrkB proteins.ConclusionDEX may regulate Bdnf/TrkB and activate the activity of the PI3K/Akt signaling pathway by targeting RAR alpha and Src, thereby inhibiting excessive autophagy and alleviating memory impairment.