文献类型：期刊文献

中文题名：大叶秦艽抗炎、调节免疫有效部位的初步研究

英文题名：Initial study of Radix Gentianae Macrophyllae on anti-inflammatory and immunoregulatory active part

作者：董建勇[1];李广远[2];李长天[2]

第一作者：董建勇

机构：[1]温州医学院,浙江温州325035;[2]甘肃中医学院,甘肃兰州730000

第一机构：温州医学院,浙江温州325035

年份：2006

卷号：23

期号：1

起止页码：17

中文期刊名：甘肃中医学院学报

外文期刊名：Journal of Gansu College of Traditional Chinese Medicine

基金：甘肃省教育厅科研基金资助项目(024-02)

语种：中文

中文关键词：大叶秦艽;抗炎;调节免疫;有效部位

外文关键词：Radix Gentianae macrophyllae ; anti-inflammatory ; immunoregulatory ; active part

摘要：目的:研究大叶秦艽抗炎、调节免疫的有效部位。方法:复制大鼠佐剂性关节炎(AA)模型,观察大叶秦艽四个溶剂部位的抗炎作用;采用刀豆素A(ConA)诱导脾T淋巴细胞的增殖反应,通过体内、外实验,分析对脾T淋巴细胞增殖作用。结果:大叶秦艽石油醚部位(QS)、正丁醇部位(QZ)、水溶部位(QW)对福氏完全佐剂引起的局部炎症和免疫性炎症有抗炎作用;QZ体内对ConA诱导的大鼠脾T淋巴细胞增殖有抑制作用,而体外四种提取物对ConA诱导的脾T淋巴细胞增殖均呈现出抑制作用。结论:大叶秦艽石油醚、正丁醇、水提取物均有抗炎作用,正丁醇提取物有调节免疫作用。
Objective ： To research the anti-imflammatory and immunoregulatory active part of Radix Gentianae macrophyllae. Methods： Rats model of adjuvant arthritis （AA） were established to observe the anti-inflammatory effect of 4 solvent parts of Radix Gentianae macrophyllae. The proliferation reaction of T lymphocytes induced by ConA was used to analyse the impress of Radix Gentianae macrophyllae on the proliferation of T lymphocytes in spleen. Results：Radix Gentianae macrophyllae had anti-inflammatory effect on the local inflammation caused by Freund＇s complete adjuvant, and its active parts were QS, QZ and QW. QZ parts had inhibitive effect on the rats＇ splenic T lymphocyte proliferation induced by ConA in vivo, and QS, QY, QZ and QW parts had the effect in vitro. Conclusion：Radix Gentianae macrophyUae has anti-inflammatory and immunoregulatory effect.