文献类型：期刊文献

英文题名：The gut microbiota in osteoporosis: dual roles and therapeutic prospects

作者：Xie, Xingwen[1];Liu, Hao[2];Wan, Kangwei[2];Li, Jiawen[2];Qi, Peng[2]

第一作者：Xie, Xingwen

通信作者：Qi, P[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105016096868);WOS:【SCI-EXPANDED(收录号:WOS:001570780300001)】；

基金：The author(s) declare financial support was received for the research and/or publication of this article. This research was supported by the National Nature Fund Regional Project (82160911, 81860864), Central University Basic Scientific Research Business Expenses Project (31920210041), The special project of science and technology development under the guidance of the central government (YDZX20206200002356).

语种：英文

外文关键词：gut-bone axis; short-chain fatty acids; osteoimmunology; FMT; probiotics; bone mineral density

摘要：Recent advances in bone biology have underscored the essential role of the gut microbiota in maintaining skeletal homeostasis. Gut-derived metabolites, particularly short chain fatty acids and tryptophan derivatives, influence bone metabolism through modulation of immune signaling, inflammation, and endocrine networks. Emerging evidence indicates that these effects are context dependent and dose dependent, rather than uniformly beneficial or detrimental. For instance, butyrate and lipopolysaccharide exhibit biphasic effects on both osteogenesis and osteoclastogenesis, contingent on concentration, immune status, and the local microenvironment. Microbiota-targeted strategies such as probiotics, prebiotics, and fecal microbiota transplantation are under active investigation as innovative interventions for osteoporosis in both preclinical and clinical contexts. However, substantial knowledge gaps persist, including inconsistent therapeutic outcomes, limited mechanistic insight into host-microbiota interactions, and the absence of standardized microbial intervention protocols. In addition, safety concerns related to FMT, particularly in immunocompromised elderly populations, emphasize the need for rigorous donor screening, extended follow-up periods, and personalized risk and benefit assessment models. To advance the field, future studies should incorporate multi-omics platforms and precision medicine tools to identify key microbial targets and enhance therapeutic efficacy. This review consolidates current evidence and proposes a conceptual framework to clarify the context-specific roles of the gut microbiota in bone remodeling. A deeper mechanistic understanding will be crucial for translating microbiota-based strategies into safe and effective treatments for metabolic bone disorders.