文献类型：期刊文献

中文题名：“近眼三针”联合腺苷钴胺注射液治疗非动脉炎性前部缺血性视神经病变40例临床观察

英文题名：Clinical observation on the treatment of 40 cases of non-arteritic anterior ischemic optic neuropathy with“needling in 3 points around eye”combined with adenosine cobalt amine injection

作者：颉瑞萍[1];刘雪[1];周勇[2];曹水清[1];张文晶[1]

第一作者：颉瑞萍

机构：[1]甘肃中医药大学附属医院眼科,甘肃兰州730020;[2]兰州市第二人民医院眼科,甘肃兰州730046

第一机构：甘肃中医药大学第二附属医院

年份：2023

卷号：40

期号：5

起止页码：75

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：兰州市科技发展指导性计划项目(2020-ZD-130);甘肃中医药大学附属医院院内创新基金项目(KC2018-19)。

语种：中文

中文关键词：非动脉炎性前部缺血性视神经病变;“近眼三针”;腺苷钴胺注射液;最佳矫正视力;视野状况;视神经纤维层厚度;临床疗效

外文关键词：non-arteritis anterior ischemic optic neuropathy;“needling in 3 points around eye”;adenosine co-balt amine injection;the best corrected visual acuity;visual field condition;the retinal nerve fiber layer;clinical effi-cacy

摘要：目的 观察“近眼三针”联合腺苷钴胺注射液治疗非动脉炎性前部缺血性视神经病变(NAION)的临床疗效。方法 将80例NAION患者采用随机数字表法分为对照组和治疗组,各40例。对照组予腺苷钴胺注射液1.5 mg肌肉注射,每日1次;治疗组在对照组治疗方法的基础上予“近眼三针”针刺治疗,穴取双侧上睛明、承泣、上明,每日1次。连续治疗28 d后,比较2组的临床疗效以及治疗前后的最佳矫正视力(BCVA)、视野状况[包括平均光敏感度(MS)和平均缺损(MD)]、视神经纤维层厚度(RNFL),并进行安全性评价。结果 治疗后2组BCVA、MS数值均明显升高,MD数值均明显降低,治疗组RNFL明显增加,与同组治疗前比较差异均有统计学意义(P<0.05或P<0.01),且治疗组在提高患者BCVA、MS及增加RNFL方面,作用明显优于对照组(P<0.05);对照组总有效率为67.5%(27/40),治疗组为87.5%(35/40),2组比较差异有统计学意义(P<0.01)。结论 “近眼三针”联合腺苷钴胺注射液可明显提高NAION患者BCVA,改善患者视野状况,增加RNFL,疗效优于单纯腺苷钴胺注射液,且操作简便安全,无明显不良反应。
Objective To observe the clinical efficacy of the combination of“needling in 3 points around eye”and adenosine cobalt amine injection in the treatment of non-arteritic anterior ischemic optic neuropathy(NAION).Methods 80 NAION patients were randomly divided into a control group and a treatment group by random number table method,with 40 patients in each group.The control group received intramuscular injection of 1.5 mg of adeno-sine cobalt amine injection once a day.On the basis of the treatment method in the control group,the treatment group was treated with“needling in 3 points around eye”:Shangjingming(BL1),Chengqi(ST1),and Shangming(Ex-HN)acupoints of both sides once a day.After 28 consecutive days of treatment,the clinical efficacy,best cor-rected visual acuity(BCVA),visual field status[including mean light sensitivity(MS)and mean defect(MD)],and retinal nerve fiber layer(RNFL)of the two groups are compared before and after treatment,and their safety is evalu-ated as well.Results After treatment,the BCVA and MS values of both groups were significantly increased,while the MD values were significantly reduced.The RNFL of the treatment group was significantly increased,with statisti-cal significance(P<0.05 or P<0.01)compared to the same group before treatment.Moreover,the treatment group had a significantly better effect than the control group in improving the patient’s BCVA,MS,and increasing RNFL(P<0.05).The total effective rate of the control group was 67.5%(27/40),while the treatment group was 87.5%(35/40).The difference between the two groups was statistically significant(P<0.01).Conclusion The combination of“needling in 3 points around eye”and adenosine cobalt amine injection can significantly improve BCVA of NAION patients,improve their visual field condition,increase RNFL,and have a better therapeutic effect than adenosine cobalt amine injection alone.The operation is simple and safe,and there are no obvious adverse re-actions.