文献类型：期刊文献

中文题名：高原低氧诱导肠稳态失衡的分子机制及中药防治研究进展

英文题名：Molecular mechanism of high altitude hypoxia induced intestinal homeostasis imbalance and research progress of traditional Chinese medicine

作者：康倩[1,3];修明慧[1,2,4];张雪燕[4];杨丹[1,3];王树威[4];和建政[1,2,3];龚红霞[1,2,3];曹旺杰[1,2,3];苏韫[1,2,3]

第一作者：康倩

机构：[1]甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000;[2]甘肃中医药大学,敦煌医学与转化教育部重点实验室,甘肃兰州730000;[3]甘肃中医药大学,基础医学院,甘肃兰州730000;[4]甘肃中医药大学,公共卫生学院,甘肃兰州730000

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2023

卷号：28

期号：12

起止页码：1391

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：CSTPCD;;CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82004228);甘肃省自然科学基金(21JR11RA144);2022年度甘肃省高等学校青年博士基金(2022QB-102);甘肃省中医药管理局项目(GZKP-2021-32)。

语种：中文

中文关键词：高原低氧;肠稳态失衡;抗缺氧;炎症;氧化损伤

外文关键词：high-altitude hypoxia;intestinal ho-meostasis imbalance;anti-hypoxia;inflammation;oxidative damage

摘要：低氧是限制人群在高原生存的因素之一,能够引起呕吐腹泻、心慌气短、急性昏迷等症状。患有急性高原病的人约80%至少有一种胃肠道不适的症状,如厌食、恶心、腹泻、呕吐等。研究高原低氧所致肠损伤的病理特点、发病机制及药物防治,有利于高原胃肠道疾病的诊治。因此,本文通过总结相关文献,就高原低氧造成肠道损伤的相关研究进行系统阐述,对高原低氧造成肠道形态学、肠道细胞、肠道菌群等肠稳态的改变,引起肠道炎症、氧化损伤等机制及中药防治进行总结,以期为科研工作者和临床工作者提供借鉴及信息参考。
Hypoxia is one of the factors restrict-ing the survival of people at high altitudes,which can cause various symptoms such as vomiting,diar-rhea,palpitations,shortness of breath and acute coma.About 80%of patients with acute mountain sickness have at least one symptom of a gastroin-testinal distress(e.g.,anorexia,nausea,diarrhea,vomiting,etc.).The pathological characteristics,pathogenesis and drug treatment of intestinal inju-ry caused by high-altitude hypoxia were studied,which is conducive to the diagnosis and treatment of plateau gastrointestinal diseases.Therefore,by summarized relevant literature and systematically expounds the related researches on intestinal dam-age caused by high altitude hypoxia.We summa-rized the changes of intestinal morphology,intesti-nal cells,intestinal flora and other intestinal ho-meostasis caused by high altitude hypoxia,the mechanism of intestinal inflammation and oxida-tive damage,and the treatment of traditional Chi-nese medicine,which provide reference and infor-mation for reference for scientific research workers and clinicians.