文献类型：期刊文献

英文题名：Residential greenspace and blood lipids in an essential hypertension population: Mediation through PM_2.5 and chemical constituents

作者：Lei, Ruoyi[1];Zhang, Ling[1];Liu, Xin[2];Liu, Ce[1];Xiao, Ya[1];Xue, Baode[1];Wang, Zengwu[3];Hu, Jihong[4];Ren, Zhoupeng[5];Luo, Bin[1,6,7]

第一作者：Lei, Ruoyi

通信作者：Luo, B[1];Hu, JH[2];Ren, ZP[3]

机构：[1]Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]Hangzhou City Univ, Sch Spatial Planning & Design, Hangzhou 310015, Peoples R China;[3]Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Div Prevent & Community Hlth, Beijing 102308, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[5]Chinese Acad Sci, Inst Geog Sci & Nat Resource Res, State Key Lab Resources & Environm Informat Syst L, Beijing 100101, Peoples R China;[6]Shanghai Meteorol Bur, Shanghai Key Lab Meteorol & Hlth, Shanghai 200030, Peoples R China;[7]China Meteorol Adm, Shanghai Typhoon Inst, Shanghai 200030, Peoples R China

第一机构：Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Chinese Acad Sci, Inst Geog Sci & Nat Resource Res, State Key Lab Resources & Environm Informat Syst L, Beijing 100101, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2024

卷号：240

外文期刊名：ENVIRONMENTAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001102539400001)】；

基金：This work was supported by the Fundamental Research Funds for the Central Universities, Lanzhou University, China (lzujbky-2021-ey07), the innovative talent project of Lanzhou city (Lanzhou science and technology bureau, 2022-RC-42 to BL), the Gansu Province Young Doctoral Fund Project (2021QB-005), National Natural Science Foundation of China (NO. 42071377) and the State Key Laboratory of Resources and Environmental Information System Young Talent Fund (YPI007). We gratefully acknowledge all of the participants that contributed to this study.

语种：英文

外文关键词：Green space; Lipids; Hypertension; Particulate matter and chemical constituents; Mediation effect; NDVI

摘要：Fine particulate matter (PM2.5) adversely affects blood lipids, while residential greenspace exposure may improve blood lipids levels. However, the association between exposure to residential greenspace and blood lipids has not been adequately studied, especially in vulnerable populations (e.g. people with essential hypertension). This study aimed to assess the association between residential greenspace exposure and blood lipids, and to clarify whether PM2.5 and chemical constituents was mediator of it. We used a period (May 2010 to December 2011) from the Chinese national hypertension project. The residential greenspace was estimated using satellite-derived normalized difference vegetation index (NDVI). The generalized additive mixed model (GAMM) was used to assess the association between exposure to residential greenspace and blood lipids, and the mediation model was used to examine whether there was a mediating effect of PM2.5 and chemical constituents on that association. The exposure to residential greenspace was negatively associated with the decreased risk of dyslipidemia, especially short-term exposure. For example, the odd ratioshort-term for dyslipidemia was 0.915 (95% CI:0.880 to 0.950). This association was strengthened by physical activity and participants living in the North. PM2.5 and chemical constituents were important mediators in this association, with the proportion of mediators ranging from-5.02% to 26.33%. The association between exposure to residential greenspace and dyslipidemia in this essential hypertensive population, especially participants living in the North and doing daily physical activity, was mediated by PM2.5 and chemical constituents.