文献类型：期刊文献

英文题名：Temperature-sensitive Hydrogel: An Effective Treatment for Nasal Drug Delivery Targeting the Brain

作者：Li, Doudou[1,2];Chen, Liping[1];Chen, Yidan[1];Jiang, Lin[1,2];Wang, Rong[1];Li, Wenbin[1]

第一作者：Li, Doudou;李丹丹

通信作者：Wang, R[1];Li, WB[1]

机构：[1]China Pharm 940Th Hosp PLA Joint Logist Support Fo, Nanjing, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou 730050, Peoples R China

第一机构：China Pharm 940Th Hosp PLA Joint Logist Support Fo, Nanjing, Peoples R China

通信机构：[1]corresponding author), China Pharm 940Th Hosp PLA Joint Logist Support Fo, Nanjing, Peoples R China.

年份：2025

外文期刊名：CURRENT DRUG METABOLISM

收录：;Scopus(收录号：2-s2.0-105009885152);WOS:【SCI-EXPANDED(收录号:WOS:001512247000001)】；

基金：The article has been funded by the National Natural Science Foundation of China under Grant No. 82173738 by corresponding author Wenbin Li.

语种：英文

外文关键词：Blood-brain barrier; Drug delivery system; Basal-brain pathway; Brain targeting; Temperature-sensitive hydrogel

摘要：The brain is highly protected by physiological barriers, in which the blood-brain barrier restricts the entry of most drugs. Intranasal drug delivery is a non-invasive way of drug delivery, which can cross the blood-brain barrier and achieve direct and efficient targeted delivery to the brain. Therefore, it has great potential in application to the treatment of brain diseases. Temperature-sensitive hydrogels undergo a solution-gel transition with temperature change, and the gel form has good mucosal adsorption properties in the nasal cavity, which is commonly used for targeted delivery of drugs for brain diseases. In this article, by introducing the transport mechanism of brain targeting after nasal administration, combined with the prescription design and basic performance study of temperature-sensitive nasal hydrogel, we summarized the research on the role that temperature-sensitive hydrogel plays brain targeting after via nasal administration, aiming to provide a reference for the development of therapeutic drugs for cerebral diseases and their clinical application. A graphical summary.