文献类型：期刊文献

英文题名：LINC00958 may be a new prognostic biomarker in various cancers: A meta-analysis and bioinformatics analysis

作者：Zhang, Helin[1,2];Zhang, Guangming[1,2];Zhang, Fan[1,2];Yang, Xiaochun[2];Li, Erqiang[1,2];Wang, Bo[1,2];Xu, Peng[1,2];Zhang, Dengxiao[1,2];Guo, Lijun[2];Huang, Xiande[2]

第一作者：张虎林;张惠玲;Zhang, Helin

通信作者：Guo, LJ[1];Huang, XD[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Lanzhou, Peoples R China.

年份：2022

卷号：13

外文期刊名：FRONTIERS IN GENETICS

收录：;Scopus(收录号：2-s2.0-85142664586);WOS:【SCI-EXPANDED(收录号:WOS:000890733200001)】；

基金：This study was supported by the Natural Science Foundation of Gansu Province, China (Nos. 21JR7RA616 and 21JR7RA617); In-hospital Scientific Research Fund of Gansu Provincial Hospital, China (No. 18GSSY4-8); Gansu University of Chinese Medicine Postgraduate "Innovation Fund" project (No. 2022CX52).

语种：英文

外文关键词：bioinformatics analysis; cancers; LINC00958; lncRNA; meta-analysis; prognosis

摘要：Background: There have been many studies on long non-coding RNAs (lncRNAs) as tumor markers. LINC00958 is a lncRNA that has been studied in a variety of tumor types. This meta-analysis aims to explore the relationship between LINC00958 and clinical prognosis and pathological characteristics in various cancers.Methods: We searched for related studies from PubMed, Web of Science, The Cochrane Library and Embase (up to October 2021). The association of LINC00958 expression with clinicopathological characteristics and prognosis was evaluated using the pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs).Results: 16 studies (1,121 patients) were included in this meta-analysis, we found that overexpression of LINC00958 was associated with poor overall survival (OS) (HR = 1.84; 95% CI: 1.36-2.49; p < 0.001). We also found that LINC00958 overexpression was correlated with positive lymph node metastasis (LNM) (OR = 1.91; 95% CI: 1.39-2.63; p < 0.001), advanced degree of infiltration (OR = 1.64; 95% CI: 1.11-2.41; p = 0.013), advanced tumor-node-metastasis (TNM) stage (OR = 2.80; 95% CI: 1.48-5.33; p = 0.002). Other clinicopathological characteristics have no obvious correlation, such as age, sex, tumor size, distant metastasis, and differentiation grade (p > 0.05).Conclusion: In summary, the overexpression of LINC00958 is significantly correlated with poor OS, positive LNM, advanced degree of infiltration, and advanced TNM stage. LINC00958 might serve as a potential prognostic biomarker and therapeutic target for a variety of cancers. However, rigorous studies with large sample sizes are still needed for further research and demonstration.