文献类型：期刊文献

中文题名：围绝经期综合征动物模型研究进展

英文题名：Research Progress on Animal Models of Menopausal Syndrome:A Review

作者：周丹妮[1];卫若楠[1];康梦娇[1];陈佳[1];赵林华[2];张伟[1,2]

第一作者：周丹妮

机构：[1]甘肃中医药大学,兰州730000;[2]中国中医科学院广安门医院,北京100053

第一机构：甘肃中医药大学

年份：2021

卷号：27

期号：18

起止页码：243

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家中医药管理局“中医药传承与创新‘百千万’人才工程(岐黄工程)岐黄学者”项目(国中医药人教函[2018]284号)。

语种：中文

中文关键词：更年期;更年期综合征;围绝经期综合征;绝经期;动物模型

外文关键词：pre-menopause;climacteric syndrome;menopausal syndrome;post-menopause;animal model

摘要：为探究围绝经期综合征病理机制,寻求防治措施,需要建立与人类围绝经期综合征相类似的动物模型,进一步为药物研究、新药开发、临床应用等提供参考。该文通过主题词及关键词"围绝经期""围绝经期综合征""更年期""更年期综合征""绝经期""绝经综合征""动物"在中国知网、重庆维普、中国生物医学文献数据库(CBM),Pubmed 4个数据库检索,并对近年来国内外围绝经期综合征模型动物的选择及对应模型的优缺点进行梳理。共确定了673项研究,其中61项被纳入分析。围绝经期综合征动物模型以去势模型最为常见,免疫缺陷模型较为少用。结果显示,随着人口老龄化及社会心理压力剧增,围绝经期综合征呈高发的态势。因此,探索围绝经期综合征的机制研究尤为重要,根据实验目的、实验周期、实验技术等因素,选择合适的模型动物和造模方法是围绝经期综合征实验成功的关键。
In order to explore the pathological mechanism of perimenopausal syndrome and seek prevention and treatment measures, it is necessary to establish animal models that similar to human perimenopausal syndrome,so as to provide reference for drug research,new drug development and clinical application. In this paper, the keywords of "perimenopausal period" "perimenopausal syndrome" "menopause" "menopausal syndrome" "menopausal period" "menopausal syndrome" and "animal" were searched in China National Knowledge Infrastructure(CNKI),Chongqing Weipu,China Biomedical Literature Database(CBM)and Pubmed. In addition,the selection of domestic peripheral menopausal syndrome model animals in recent years and the advantages and disadvantages of corresponding models were summarized.A total of 673 studies were identified,of which 61 were included in the analysis. The most common animal model of perimenopausal syndrome is castration model,while the immunodeficiency model is less used. With the aging of the population and the rapid increase of psychosocial stress,the incidence of perimenopausal syndrome is high. Therefore,it is particularly important to explore the mechanism of perimenopausal syndrome.According to the experimental purpose,experimental period,experimental technology and other factors,the selection of appropriate model animals and modeling methods is the key of the success of the experiment of perimenopausal syndrome.