文献类型：期刊文献

英文题名：Does Astragalus mongholicus Bunge help promote the healing of wounds? A systematic review and meta-analysis of preclinical animal studies

作者：Zhang, Jun[1,2];Zhang, Feifei[3];Wang, Ruidan[2];Yang, Donghua[1];Wang, Bo[2];Zeng, Zhaoyang[4];Tian, Jinhui[1]

第一作者：张军;Zhang, Jun

通信作者：Tian, JH[1];Zeng, ZY[2]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Integrat Med, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Integrat Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001754743300001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by "Innovation Fund Project for University Teachers of Gansu Provincial Department of Education" (Grant No. 2024A-093 and 2025A-119)".

语种：英文

外文关键词：Astragalus mongholicus Bunge; meta-analysis; preclinical study; systematic review; wound healing

摘要：Background Wounds continue to represent a significant public health challenge globally. In recent years, Astragalus mongholicus Bunge, a traditional Chinese botanical drug utilized for wound treatment, has garnered increasing research attention. However, the therapeutic efficacy and safety of this natural botanical drug on wound healing remain poorly understood. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of Astragalus mongholicus Bunge in animal wound models to propel future studies towards definitive preclinical and initial clinical trials. Methods A systematic search of seven databases was conducted to identify randomized controlled studies that compared Astragalus mongholicus Bunge to placebo or a "no treatment" arm in animal models of skin wounds. Two authors independently assessed the risk of bias of the included studies using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool for preclinical animal studies and extracted relevant information according to a predesigned extraction form. Random effects models were used to estimate the pooled effect and the data were analyzed using R software. Results Finally, 20 citations (including 21 studies) with 559 animals were included. The meta-analysis revealed that compared to the control group, wounds treated with Astragalus mongholicus Bunge had a higher wound contraction percentage [standardized mean difference 4.18, 95% confidence interval 2.40-5.96, P < 0.0001]. Additionally, the Astragalus mongholicus Bunge treatment group exhibited a positive effect in enhancing angiogenesis, facilitating collagen deposition, and diminishing pro-inflammatory factors. Meantime, no harmful events were reported. Conclusion Astragalus mongholicus Bunge presented positive effects on the process of wound healing in experimental models used, demonstrating the huge potential of this botanical drug for wound treatments. More studies with comparable study protocols should be performed to validate the results of the present systematic review and meta-analysis.