文献类型：期刊文献

中文题名：舒肝消积丸对实验性肝损伤的保护作用

英文题名：PROTECTIVE EFFECT OF SHUGAN XIAOJI WAN ON EXPERIMENTAL HEPATIC INJURY

作者：黄正良[1];崔祝梅[1];任远[1];张坚[1];张训凯[2]

第一作者：黄正良

机构：[1]甘肃中医学院;[2]甘肃省药物研究所

第一机构：甘肃中医药大学

年份：1990

卷号：6

期号：1

起止页码：41

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：舒肝消积丸;实验性肝损伤;异硫氰酸苯酯;四氯化碳;利胆作用

外文关键词：Sugan Xiaoji Wan; Experimental hepatic injury; APIT; CCL; Cholagogic action

摘要：舒肝消积丸5～10mg/kg,用药5～6天,对异硫氰酸苯酯和四氯化碳诱发急性肝损伤所引起SGPT升高有非常明显的降低效应,并能明显对抗异硫氰酸笨酯引起的SB上升,病理组织学检查可见本品能减轻肝细胞变性、坏死。此外,舒肝消积丸还能增加家兔胆汁流量,保护小鼠因四氯化碳中毒引起的戊巴比妥钠睡眠时间的延长。
With Shugan Xiaoji Wan, 5-10g/kg, ior 5 - 6 days' treatment, We can produce lowering action on the acute hepatic injury of rat induced by APIT and Aon the rising of SGPT caused by CC14 induce acute hepatic injury of rat. This pill possesses apparnet anti-SB-rising action caused by APIT, thus, it has distinctive effect on the treatment of experiment jaundice. Histopathological examination shows that this medicine can alleviate the condition of the degeneration of hepatic cells and that of necrosis. Moreover, it can also increase the biliation flow of rabbit and protect the mouse, after having been poisoned by CCl4, from suffering sleep induction period and the prolongation of recovery when applying Pentobarbital sodium.