文献类型：期刊文献

英文题名：GCN5L: a critical target in energy metabolism pathways

作者：Kou, Yushun[1];Ma, Ruiling[1];Wang, Yiyuan[1];Chen, Xiaojie[2];Li, Bin[1];Wu, Tao[2];Gu, Yuanhui[2];Yi, Lin[1]

第一作者：Kou, Yushun

通信作者：Yi, L[1];Gu, YH[2]

机构：[1]Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Surg Dept, Lanzhou, Peoples R China

第一机构：甘肃中医药大学中西医结合学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Surg Dept, Lanzhou, Peoples R China.|[10735ed249c6606940a33]甘肃中医药大学中西医结合学院;[10735]甘肃中医药大学;

年份：2025

卷号：13

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：;Scopus(收录号：2-s2.0-105019259651);WOS:【SCI-EXPANDED(收录号:WOS:001596509500001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by grants from National Natural Science Foundation of China (82160842); Dunhuang Medicine in the transformation of the Ministry of Education key laboratory open project (DHYX23-07); General project of Joint Research Fund: Project name: Study on the protective effect of Wuwei Han Jian "Yu Fang" on hypertensive kidney injury (23JRRA1521); Science and Technology Department of Gansu Province, Natural Science Foundation of Gansu Province, miR143 on thyroid papillary carcinoma and intervention of ursolic acid (24JRRA590). Gansu University of Chinese Medicine and Gansu Provincial People's Hospital provided financial and research project support for the author's article.

语种：英文

外文关键词：GCN5L; energy metabolism; epigenetics; cellular stress; clinical applications

摘要：GCN5L (GCN5-like protein), as a core component of a novel epigenetic-regulatory complex, exerts precise control over mitochondrial metabolic enzyme activity through acetylation modifications. It not only drives energy production but also regulates key processes like lipid metabolism and cellular stress responses. As research on GCN5L advances, exploring its specific regulatory mechanisms and functionality across physiological states has drawn growing interest from researchers. Drawing on 76 studies from CNKI, PubMed, and Web of Science, this review synthesizes current research advances on GCN5L. It aims to elucidate GCN5L's physiological significance as a critical target in energy metabolism, providing valuable references for related disciplines and advancing both theoretical understanding and practical applications in metabolic regulation.