文献类型：期刊文献

英文题名：First trimester hepatic steatosis index as a predictor of gestational diabetes mellitus: a cohort study in Northwestern China

作者：Liu, Xuhui[1];Dai, Xuegang[2];Guo, Zhiru[1];Ma, Rui[2];Li, Fei[1];Zhang, Ling[2];Liu, Yining[1];Liang, Lixia[2];He, Jian[2];Wang, Yanxia[2]

第一作者：刘晓惠

通信作者：He, J[1];Wang, YX[1]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730101, Peoples R China;[2]Gansu Prov Matern & Child Care Hosp, Clin Trial Facil Off, Lanzhou 730050, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Prov Matern & Child Care Hosp, Clin Trial Facil Off, Lanzhou 730050, Peoples R China.

年份：2025

卷号：15

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：;Scopus(收录号：2-s2.0-105009877762);WOS:【SCI-EXPANDED(收录号:WOS:001522987100037)】；

基金：The authors thank the funding from the Science and Technology Department of Gansu Province.

语种：英文

外文关键词：Gestational diabetes mellitus; Hepatic steatosis index; Cohort study; Predictive value; First trimester

摘要：To investigate the predictive value of the hepatic steatosis index (HSI) in the first trimester for gestational diabetes mellitus (GDM), and explore the association between HSI and the risk of developing GDM. A total of 2795 pregnant women were included in this cohort study. Maternal baseline data and basic laboratory data, including alanine aminotransferase, aspartate aminotransferase, fasting plasma glucose (FPG), and others were collected during 8-13 weeks of gestation. The 75-g oral glucose tolerance test was conducted at 24-28 weeks of gestation, and according to the criteria of American Diabetes Association, the participant would be diagnosed as GDM if one of the thresholds was met: fasting blood glucose >= 5.1 mmol/L, 1-h blood glucose >= 10.0 mmol/L, or 2-h blood glucose >= 8.5 mmol/L. The relationship between first-trimester HSI and GDM outcomes was analyzed by using Logistic Regression, Restricted Cubic Spline and Subgroup Analyses. The nomogram model including HSI, FPG and other factors was established, and diagnostic efficacies of the nomogram model, FPG, HSI, and white blood cell count (WBC) were analysed by using the receiver operating characteristic curve. 212 pregnant women were diagnosed with GDM among 2,795.After adjusting for the covariates, compared to women in the lowest quartile (Q1), those in the highest quartile group (Q4) of first-trimester HSI had a 2.328-fold risk of developing GDM (95% CI 1.262-4.295, p < 0.05). There was a positive nonlinear dose-response relationship between the first-trimester HSI and GDM (p for overall < 0.001; p for nonlinear = 0.010). Subgroup analyses found that HSI didn't interact with covariates such as age, gravidity, parity, etc. (p > 0.05). The diagnose efficacies of the nomogram model, HSI, FPG and WBC were 0.737 (95% CI 0.702-0.773), 0.696 (95% CI 0.658-0.734), 0.631 (95% CI 0.593-0.670), and 0.569 (95% CI 0.526-0.611), respectively. First-trimester HSI, FPG, WBC, and age may jointly predict the occurrence of GDM.