文献类型：期刊文献

中文题名：OPG-RANKL-RANK信号系统是调节破骨细胞及骨质疏松症的重要途径

英文题名：OPG-RANKL-RANK signaling system is an important approach to regulate osteoclasts and osteoporosis

作者：黎彦龙[1];何明[1];陈秉雄[1,2];陈秉虎[1,3];王君霞[4];王天学[1];韦宏[1];宋敏[2]

第一作者：黎彦龙

机构：[1]临洮县人民医院,甘肃省定西市730500;[2]甘肃中医学院,甘肃省兰州市730000;[3]兰州大学药学院,甘肃省兰州市730000;[4]临洮县八里铺卫生院,甘肃省定西市730515

第一机构：临洮县人民医院,甘肃省定西市730500

年份：2015

卷号：19

期号：24

起止页码：3894

中文期刊名：中国组织工程研究

外文期刊名：Chinese Journal of Tissue Engineering Research

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；

基金：国家自然科学基金(81360554);甘肃省省青年科技基金计划(1208RJYA066)~~

语种：中文

中文关键词：组织构建;骨组织工程;骨质疏松症;OPG-RANKL-RANK信号系统;破骨细胞;国家自然科学基金

外文关键词：Osteoporosis;RANK Ligand;Osteoprotegerin;Osteoclasts

摘要：背景:OPG-RANKL-RANK信号系统在破骨细胞对于骨吸收机制中的重要作用。目的:归纳总结OPG-RANKL-RANK信号系统在破骨细胞、骨质疏松症中的表达,以及OPG-RANKL-RANK信号系统靶向治疗的前瞻性。方法:在国内外期刊数据库中检索近10年内国内外文献,按关键词:骨保护素,RANKL,RANK,破骨细胞,骨质疏松症;OPG,osteoclast,osteoporosis,检索相关文献,筛选出符合纳入标准的文献,对文献进行质量评估后采纳。结果与结论:OPG-RANKL-RANK信号系统以及相关联的信号途径是介导破骨细胞发育、成熟的重要信号途径,并且是导致骨质疏松症的机制,在基因及分子水平上,靶向治疗骨质疏松症已成为人们的关注点。基于OPG-RANKL-RANK信号系统靶向可成为治疗为骨质疏松症的研究提供平台,OPG-RANKL-RANK信号系统是调控破骨细胞及骨质疏松症的重要途径。
BACKGROUND：The OPG-RANKL-RANK transport system plays a crucial role in bone resorption mechanism of osteoclasts. OBJECTIVE：To observe the expression of OPG-RANKL-RANK signaling system in osteoclasts, osteoporosis, and the targeted therapy of OPG-RANKL-RANK signaling system. METHODS：We retrieved related literatures in the periodicals database with the key words of“osteoprotegerin, RANKL, RANK, osteoclasts, osteoporosis”in English and Chinese. According to the inclusion criteria, the literatures were included in this study after the evaluation of quality. RESULTS AND CONCLUSION：The mature of osteoclasts is mediated via OPG-RANKL-RANK signaling system and its associated signaling pathways. This signal pathway leads to the mechanism of osteoporosis. At the genetic and molecular levels, the targeted therapy of osteoporosis has become the focus. OPG-RANKL-RANK signaling＆amp;nbsp;system can provide a research platform for targeted treatment of osteoporosis, and OPG-RANKL-RANK signaling system is an important way to the regulation of osteoclasts and osteoporosis.